01). Post-LT AKI by AKIN criteria was numerically higher in the CKD group (48% v 28%, p=0.07), though similar by RIFLE-R (41% v 38%, p=0.76) and RIFLE-I (16% v 14%, p=0.80)

criteria. The 4 year cumulative incidences of CKD and death were 68.5% and 24.9%, respectively. uNGAL 24 hours post-LT was the most predictive time point for CKD (AUC 0.65), with uNGAL>93 ng/ml being highly predictive of CKD (log rank p=0.002, PPV 100%, NPV 36%). The final multivariable model for the prediction of time to CKD included uNGAL at 24 hours (HR1.09 per 100 ng/ml, p=0.03), age at LT (HR 1.41 per decade, p=0.048), HCV (HR 1.86, p=0.04), and BMI (<30 ref, 30≤BMI>35 HR 1.04, p=0.92, 35≤BMI>40 HR 4.76, p=0.007, BMI≥40 HR 1.86, p=0.27). All patients who died post-LT developed EPZ6438 CKD prior to death (p<0.001). 24 hour post-LT uNGAL>30 ng/ml was predictive of death (log rank p=0.05, PPV 32%, NPV 87%). Additional predictors of time to death in multivariable modeling included age at LT (HR 3.02 per decade, p=0.002), HCV (HR 3.0, p=0.048), BMI (<30 ref,

30≤BMI>35 selleck inhibitor HR 6.01, p=0.005, 35≤BMI>40 HR 1.12, p=0.85, BMI≥40 HR 3.18, p=0.33), CIT (HR 1.21 per hour, p=0.002) and EBL (HR 1.15 per liter, p=0.02). Conclusions: uNGAL predicts not only early post-LT AKI, but also the development of long-term CKD, in this cohort with preserved pre-LT kidney function. Given the significant correlation between CKD and death, such early predictors could be used to guide preventative interventions. Disclosures: Elizabeth C. Verna – Advisory Committees or Review Panels: Gilead; Grant/ Research Support: Salix, Merck Robert S. Brown – Advisory Committees or Review Panels: Vital Therapies; Consulting: Genentech, Gilead, Merck, Abbvie, Janssen; Grant/Research

Support: Gilead, Merck, Vertex, AbbVie, Salix, Janssen, Vital Therapies The following people have nothing to disclose: Giuseppe Cullaro, Joseph F. Pisa, Gebhard Wagener BACKGROUND. Declining physical capacity, deconditioning, is thought to cause poor outcomes among patients awaiting liver transplantation. Very little is known about the ability of tests of deconditioning to predict adverse pre-transplant end-points, or whether measured deconditioning has predictive value independent of MELD and Child scores. We hypothesized that measured deconditioning would predict deaths and morbidity expressed as inpatient hospital days Cytidine deaminase caused by the complications of cirrhosis. METHODS. We measured deconditioning in 218 patients evaluated or listed for transplantation using a simple test, dominant hand grip strength, known to predict outcomes in large chronic disease populations. We used Poisson regression stratified by gender to determine whether grip testing was associated with the number of inpatient days between the test date and the end of a 6 month observation period. A multivariable Poisson model was used to test grip strength, MELD and Child scores as covariates against the outcome of inpatient days.