1 for all outcomes). No significant publication bias with regard to LTP was observed using the funnel selleckchem plot. Conclusions: To
our knowledge, this is the first meta-analysis comparing the two modalities in treating primary HCC. Based on the available evidence, both RFA and MWA are equally safe and effective. However, the results should be interpreted with caution because of the different types of generators and antennas used in these studies. Further well designed randomized controlled trials using current generators with high power output and with larger sample sizes are warranted to confirm these findings. MA CHINNARATHA,1 R MCCORMICK,2 R WUNDKE,2 RJ WOODMAN,1 AJ WIGG1,2 1School of Medicine, Flinders University of South Australia, 2Gastroenterology/Hepatology, Flinders Medical Centre, Bedford Park, SA Background and Aims: Bone
disease (BD) is a major complication of cirrhosis. Previous studies investigating the prevalence of BD in cirrhosis have focused on patients with a single etiology or those awaiting liver transplant. Our aim was to determine the prevalence of BD (both osteopenia and osteoporosis) in an unselected cohort of cirrhotic patients with mixed etiology and severity; and to determine risk factors for BD in cirrhosis. Methods: A single center review of prospectively collected data for buy MK-1775 consecutive patients newly diagnosed with cirrhosis between Sep 2009 and Dec 2012. All patients underwent Bone Mineral Density (BMD) assessment using Dual Energy X-ray Absorptiometry (DEXA) within 3 months of diagnosis. Relevant clinical and biochemical data were collected on diagnosis and with follow-up patient survey. Osteoporosis was defined as a T-score 上海皓元医药股份有限公司 <−2.5 SD. Binary logistic regression was used to determine
risk factors associated with BD (T-score <−1 SD or a Z-score <−2 SD). Results: Data was collected for a total of 406 subjects (67% males) with a mean (±SD) age of 56.2 (±10.9) years. Alcohol (41.1%), hepatitis C (HCV) + alcohol (16.5%) and HCV (16%) were the most common etiologies. 84% of patients were either Childs-Pugh class A or B with a mean MELD (±SD) score of 12.4 (±5.7). The prevalence of BD was 56% of the total cohort. Osteoporosis was present in 20.5% (66/320) of patients with a T-score measurement. Moderate or severe vitamin D deficiency (≤50 nmol/L) was present in 54% (212/389) and fragility fractures in 3.3% (12/362) of patients. In multivariate analysis, only older age and lower BMI were significant independent risk factors for BD (Table) with both displaying a linear trend. Amongst females, high serum FSH level, irrespective of menopausal status, was associated with BD in univariate analysis [OR (95%CI) = 1.01 (1.00–1.03), p = 0.04] but was no longer associated with BD after adjustment for age and BMI. Conclusion: This is the largest study of bone disease in unselected cirrhotic subjects with mixed etiology and disease severity.