(2011). Degree (strength) was calculated see more as the sum of binary (weighted) edges on a node at a given threshold. Participation coefficients and within-module Z scores were calculated after Guimerà and Nunes Amaral (2005) on thresholded graphs. Relevant formulas are provided below. Degree for node i   is defined as ki=j∑Aijki=∑jAij, where AijAij is the adjacency matrix of the graph. Within-module Z score for node i   is defined as zi=êi−ê¯si/ósi, where êiêi is the number of edges of node i   to other nodes in its module sisi, ê¯si is the average of êê over all the nodes in sisi, and ósiósi is the standard deviation of êê in sisi. Participation index for node i   is defined as Pi=1−∑s=1NM(êis/ki)2, where êisêis is the number

of edges of node i   to nodes in module s  , kiki is the degree of

node i  , and NMNM is the total number of modules in the graph. In Figure 6, the areal graph was analyzed at nine thresholds (10%–2% edge density in 1% steps), and the participation coefficients arising from InfoMap community assignments were summed and plotted as the proportion of the theoretical upper bound attainable over thresholds. In Figure 7, the modified voxelwise network was analyzed at five thresholds (2.5%–0.5% edge density in 0.5% steps; these thresholds all displayed complex community structure and focal articulation points, see Figure S4), and the number of unique communities present within a certain radius of the Cisplatin chemical structure center of a source voxel was calculated using InfoMap community assignments. Radii of 5–10 mm in 1 mm steps were sampled. Thus Figure 7 shows the results pooled from the 30 analyses (5 thresholds × 6 radii; each analysis normalized to its maximal value). MRI preprocessing and RSFC processing were performed with in-house software. Network calculations were performed

in Matlab (2007a, The Mathworks, Natick, MA). Brain visualizations were created with Caret software and the PALS surface (Van Essen, 2005 and Van Essen et al., 2001). Consensus assignments from Power et al. (2011) are available at http://sumsdb.wustl.edu/sums/directory.do?id=8293343&dir_name=power_Neuron11. The real-world graphs presented in Figure 3, Figure 4, and Figure S1 are publicly available data sets (http://www-personal.umich.edu/∼mejn/netdata/). The citations for the networks are as follows: yeast protein, Jeong et al. (2000); network science cocitation, Newman (2006); political blogs, Adamic and Glance (2005); Les Miserables word co-occurrence, Knuth (1993); high-energy theory collaborations, Newman (2001); NCAA football, Girvan and Newman (2002); USA power grid, Watts and Strogatz (1998); C. elegans neural network, Watts and Strogatz (1998); karate club, Zachary (1977); dolphins, Lusseau et al. (2003); Internet, Mark Newman, unpublished; macaque, Harriger et al. (2012); jazz musicians, Gleiser and Danon (2003); PGP, Boguñá et al. (2004); GDP, Frank and Asuncion (2010); GDP by country in present-day dollars, 1969–present, http://www.ers.usda.