6/472 (127%) P = 0045 1/751 (0133%) vs 12/472 (254%) P ≤ 00

6/472 (1.27%) P = 0.045 1/751 (0.133%) vs. 12/472 (2.54%) P ≤ 0.001 1/751 (0.133%) vs. 1/472 (0.21%) P = 1.0 7/164 (4.26%) vs. 19/472 (4.02%) P = 0.89 5/164 (3.05%) vs. 6/472 (1.27%) P = 0.13 2/164 (1.21%) vs. 12/472 (2/54%) P = 0.49 0/164 (0) vs. 1/472 (0.21%) P = 1.0 Significant number of Celecoxib users who had switched over

to non-selective NSAIDs developed gastritis after the change-over (6.1% vs 1.21%; p = 0.018). (6.1% vs 1.21%; p = 0.018). Adverse effects during the non-selective NSAID period appeared much earlier (6.08 ± 5.3 months) as compared to 15.75 ± 9.82 months during the Celecoxib period (p = 0.001) (Table 4). On the other hand, patients who were on multiple non-selective NSAIDs Dabrafenib (Group IIb) showed significantly higher overall side effects (13/204, 6.37% vs. 6/268, 2.23%; P = 0.023) and GI side effects (10/204, 4.9% vs. 2/268, 0.74%; P = 0.04), as compared to patients who were only on a single NSAID (Group IIa). NSAIDs are widely prescribed for pain relief in all rheumatological conditions because of their ability to curb inflammation and optimize function. They have been proven to be more efficacious than paracetamol for management of pain and improvement of quality of life.[14] This study was undertaken in the wake of the Rofecoxib controversy, to study the toxicity profile

of Celecoxib in an Asian Indian population. Globally there was a steep decline in the use of COX-2 inhibitors following withdrawal of Rofecoxib.[15] As compared to Rofecoxib, COX-2 inhibition is less with Celecoxib.[16] Thus, thrombogenic effects check details of Celecoxib are expected to be less than Rofecoxib. No thrombo-embolic events were reported with the use of Celecoxib for more than 3 months in our patients with rheumatic diseases. The most significant observation in

this cohort was the development of new onset hypertension in young patients using Celecoxib, as compared to those who had used non-selective NSAIDs. This finding is in stark contrast to two other studies which have shown Celecoxib to have a significantly Buspirone HCl lower incidence of hypertension when compared to ibuprofen,[17] and an equal risk of developing new onset hypertension as compared to diclofenac.[18] No significant hypertension was observed in those Celecoxib users who had switched over to other non-selective NSAIDs. This may suggest a cause–effect relationship between the two in this population. Muscara et al. have described elevation of blood pressure and leukocyte adherence in rats on suppression of COX-2. They have proposed that the hypertensive effects of Celecoxib may be due to its effects on renal function and on postacyclin synthesis.[19] However, this needs to be tested prospectively. Ambulatory blood pressure data has suggested a 2–4 mmHg increase in systolic blood pressure over 4 h after dosing with Celecoxib.[20] Due to the relatively short half-life of Celecoxib, Solomon et al.

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