A 61-year-old postmenopausal woman was treated with toremifene as an adjuvant therapy for breast cancer. A cystic mass developed during the treatment, with gradual growth in the uterine myometrium. The patient was treated with hysterectomy and bilateral salpingo-oophorectomy,

and the tumor was diagnosed as low-grade ESS (stage IA) with estrogen-receptor and progesterone-receptor. The patient discontinued toremifene and has been progression-free for 21 months. Our data suggest that toremifene might be associated with the development of ESS in certain patients through its estrogen-like effects in the uterus.”
“”"Exploratory Study about the Prescription Pattern of Medicines containing Hypericum perforatum Extracts by Psychiatrists in Porto Alegre (Brazil)”". The aim of this ZD1839 study was to assess the prescription pattern of medicines containing Hypericum perforatum extracts by psychiatrists in Porto Alegre – RS. It constituted a transversal,

investigational study performed by using a structured interview. The most of the interviewed physicians (37) do not prescribe medicines containing extracts of Hypericum perforatum, because they don’t believe these products are effective and safe. However they declared to have knowledge about the use of Hypericum for treating mild to moderate depression by reading scientific papers and biomedical books. Two psychiatrists informed they prescribe these medicines when the patients can’t bear the adverse effects CBL0137 in vivo of the standard antidepressants.

They have considered the therapeutic outcome as regular to good, and did not observe significant adverse reactions. The results indicate the psychiatrists have knowledge about the use of medicines containing extracts of Hypericum 3-MA mouse perforatum as antidepressants. Nevertheless, the prescription is not common.”
“Among uterine cystic tumors, uterine cyst arising from secondary Mullerian epithelium is exceedingly rare. A 45-year-old woman presented with pelvic cystic mass, which was initially diagnosed as a paraovarian cyst by ultrasound and magnetic resonance imaging. At laparoscopy, the cyst proved to be a pedunculated uterine cyst, which was easily resected. Histologically, the cyst wall was lined by fallopian epithelium and positively stained for WT-1, estrogen receptor, and progesterone receptor. The final diagnosis was Mullerian cyst of the uterus. Preoperative diagnosis of uterine Mullerian cyst is usually impossible. Laparoscopy is useful as a minimally invasive treatment to diagnose and resect the cyst at the same time. Specific immunostaining is useful to make a definite diagnosis of Mullerian cyst of the uterus.”
“The present study was undertaken to evaluate immunomodulatory activity of Crocus sativus and its active constituent crocin. Crocus sativus and crocin were administered orally at doses of 50 mg/kg and 9.