Although limited to the present sample, such finding would indicate that reduced semantic CFTR high throughput screening fluency is the most distinctive cognitive trait of OCD and that the cognitive processing abnormalities underlying the observed deficit might be etiological relevant factors in the disorder, though distinct from other assumed pathogenic factors such as brain circuitry anomalies. Indeed, individual Inhibitors,research,lifescience,medical variation in the semantic fluency performance was correlated in the OCD sample, with diffusivity changes in three areas (the left inferior temporal gyrus, the left precuneus and the right inferior

parietal gyrus) so that the semantic fluency score decreased as MD values increased, though no microstructural

differences were observed in these regions between OCD and HC. Actually, the role of the left temporal lobe in semantic fluency is well-established by functional Inhibitors,research,lifescience,medical imaging studies showing that particularly the left inferior temporal cortex is more involved in word retrieval according to given categories (e.g.: Gourovitch et al. 2000; Grogan et al. 2009; Mummery et al. 1996; Heim et al. 2008). On the other hand, the association between the semantic fluency Inhibitors,research,lifescience,medical score and the microstructural integrity of the left precuneus is less expected, although it might be related to use of a Inhibitors,research,lifescience,medical visual search strategy. Indeed, even if the categorical

fluency task is primarily a semantic auditory task, participant often report recourse to strategies more based on visual imagery. It is thus conceivable that owing to the microscopic alterations in temporal structures responsible for semantic memory, OCD patients did not recur to a semantic association strategy to unravel the task, but rather Inhibitors,research,lifescience,medical relied on a visual imagery search strategy, though the latter was somehow impeded by loss of normal microstructure in the Resminostat left precuneus. A negative correlation between performance in the semantic fluency task and microstructural tissue integrity was also observed in the right parietal cortex, a region probably implicated in the control of switching across different stimuli (see Gurd et al. 2002). As semantic fluency requires not only the ability to cluster words within a given category but also the capacity to switch efficiently to a new subcategory, it is possible that the observed loss of microstructural tissue integrity in the parietal lobe might have hindered the ability to shift efficiently between subcategories, hence determining the observed reduced category fluency in our OCD sample.