Bioorg Med Chem Lett 13:855–868CrossRef Nakajima Y, Hamashima H,

Bioorg Med Chem Lett 13:855–868CrossRef Nakajima Y, Hamashima H, Washizuka K, Tomishima Y, Ohtake H, Imamura E, Miura T, Kayakiri H, Kato M (2005) Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist. Bioorg Med Chem Lett 15:251–254CrossRefPubMed Naylor EM, Colandrea VJ, Candelore MR, Cascieri MA, Colwell LF Jr, Deng L, Feeney WP, Stattic Forrest MJ, Hom GJ,

MacIntyre DE, Strader CD, Tota L, Wang PR, Wyvratt MJ, Fisher MH, Weber AE (1998) 3-Pyridylethanolamines: potent and selective human beta 3 adrenergic receptor agonists. Bioorg Med Chem Lett 8:3087–3092CrossRefPubMed Naylor EM, Parmee ER, Colandrea VJ, Perkins L, Brockunier L, Candelore MR, Cascieri MA, Colwell LF Jr, Deng L, Feeney WP, Forrest MJ, Hom GJ, MacIntyre DE, Strader CD, Tota L, Wang PR, Wyvratt MJ, TPCA-1 research buy Fisher MH, Small molecule library Weber AE (1999) Human beta3 adrenergic receptor agonists containing imidazolidinone and imidazolone benzenesulfonamides. Bioorg Med Chem Lett 9:755–758CrossRefPubMed Ok HO, Reigle LB, Candelore MR, Cascieri MA, Colwell LF, Deng L, Feeney WP, Forrest MJ, Hom GJ, MacIntyre DE, Strader CD, Tota L, Wang P, Wyvratt MJ, Fisher MH, Weber AE (2000) Substituted oxazole benzenesulfonamides as potent human beta3 adrenergic receptor agonists. Bioorg Med Chem Lett 10:1531–1534CrossRefPubMed Oprea TI, Waller CL, Marshall GR (1994) Three-dimensional quantitative structure–activity

relationship of human immunodeficiency virus (I) protease inhibitors. 2. Predictive power Casein kinase 1 using limited exploration of alternate binding modes. J Med Chem 37:2206–2215CrossRefPubMed Parmee ER, Ok HO, Candelore MR, Tota L, Deng L, Strader CD, Wyvratt MJ, Fisher MH, Weber AE (1998) Discovery of L-755, 507: a subnanomolar human beta 3 adrenergic receptor agonist. Bioorg Med Chem Lett 8:1107–1112CrossRefPubMed Parmee ER, Naylor EM, Perkins L, Colandrea VJ, Ok HO, Candelore MR, Cascieri MA, Deng L, Feeney WP, Forrest MJ, Hom GJ, MacIntyre DE, Miller RR, Stearns RA, Strader CD, Tota L,

Wyvratt MJ, Fisher MH, Weber AE (1999) Human beta3 adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides. Bioorg Med Chem Lett 9:749–754CrossRefPubMed Prathipati P, Saxena AK (2005) Characterization of beta3-adrenergic receptor: determination of pharmacophore and 3D QSAR model for beta3 adrenergic receptor agonism. J Comput Aided Mol Des 19:93–110CrossRefPubMed Sawa M, Tateishi H, Mizuno K, Harada H, Oue M, Tsujiuchi H, Furutani Y, Kato S (2004) Tryptamine-based human beta3-adrenergic receptor agonists. Part 2: SAR of the methylene derivatives. Bioorg Med Chem Lett 14:5963–5966CrossRefPubMed Sawa M, Mizuno K, Harada H, Tateishi H, Arai Y, Suzuki S, Oue M, Tsujiuchi H, Furutani Y, Kato S (2005) Tryptamine-based human beta3-adrenergic receptor agonists. Part 3: improved oral bioavailability via modification of the sulfonamide moiety.

Leave a Reply

Your email address will not be published. Required fields are marked *

*

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>