Cancer Res 2004, 64: 5632–42 CrossRefPubMed

29 Green NK,

Cancer Res 2004, 64: 5632–42.CrossRefPubMed

29. Green NK, Morrison J, Hale S, Briggs SS, Stevenson M, Subr V, Ulbrich K, Chandler L, Mautner V, Seymour LW, Fisher KD: Retargeting Citarinostat polymer-coated adenovirus to the FGF receptor allows productive infection and mediates efficacy in a peritoneal model of human selleck inhibitor ovarian cancer. J Gene Med 2008, 10: 280–9.CrossRefPubMed 30. Barnett BG, Crews CJ, Douglas JT: Targeted adenoviral vectors. Biochim Biophys Acta 2002, 1575: 1–14.PubMed 31. Wickham TJ: Targeting adenovirus. Gene Ther 2000, 7: 110–4.CrossRefPubMed 32. Parker AL, Waddington SN, Nicol CG, Shayakhmetov DM, Buckley SM, Denby L, Kemball-Cook G, Ni S, Lieber A, McVey JH, Nicklin SA, Baker AH: Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes. Blood 2006, 8: 2554–61.CrossRef 33. Reynolds PN, Nicklin SA, Kaliberova L, Boatman BG, Grizzle WE, Balyasnikova IV: Combined transductional and transcriptional targeting improves the specifcity of transgene expression in vivo.

Nat Biotechnol 2001, 19: 838–842.CrossRefPubMed 34. Reynolds PN, Zinn KR, Gavrilyuk SCH772984 VD, Balyasnikova IV, Rogers BE, Buchsbaum DJ: A targetable, injectable adenoviral vector for selective gene delivery to pulmonary endothelium in vivo. Mol Ther 2000, 2: 562–578.CrossRefPubMed Competing interests The authors declare that they have no competing interests. Authors’ contributions LPY carried out transfection and viral preparation, animal experiment and histological analysis, and drafted the manuscript. PC carried out TUNEL staining and performed statistical analyses. XCP contributed to animal experiment and revised the manuscript. HSS, WHH, FYC and STL contributed to animal experiment. LY offered Adenovirus and designed the topic. YQW supervised

experimental work and revised the manuscript. All authors read and approved the final manuscript.”
“Background The kinetochore learn more is a large protein complex assembled on centromere DNA and kinetochore dysfunction is an important source for chromosome instability [1, 2]. More than 60 kinetochore proteins have been identified in yeast in recent years [3–5]. Multiple kinetochore proteins have been shown to be deregulated in human cancers, which suggests an important role of kinetochore for chromosome instability and cancer development [6–9]. CENP-H was initially identified in the mouse centromere as a fundamental component of the active centromere [10, 11]. Human CENP-H presented at the inner plate of kinetochore throughout the cell cycle, co-localized with CENP-A and CENP-C, and was necessary for the appropriate localization of CENP-C [10–13].

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