Casadevall A, Pirofski LA: Accidental virulence, cryptic pathogenesis, martians, lost hosts, and the pathogenicity of environmental microbes. Eukaryot Cell 2007,6(12):2169–2174.CrossRefPubMed 12. Steenbergen JN, Shuman HA, Casadevall A: Cryptococcus neoformans interactions with amoebae suggest an explanation for its virulence and intracellular pathogenic strategy in macrophages. Proc Natl Acad Sci USA 2001,98(26):15245–15250.CrossRefPubMed 13. Steenbergen JN, Nosanchuk JD, Malliaris SD, Casadevall A: Cryptococcus neoformans virulence is enhanced after growth in the genetically malleable host Dictyostelium discoideum. Infect Immun 2003,71(9):4862–4872.CrossRefPubMed selleck kinase inhibitor 14. Casadevall A: Fungal

virulence, vertebrate endothermy, and dinosaur extinction: is there a connection? Fungal Genet Biol 2005,42(2):98–106.CrossRefPubMed 15. Casadevall A, Steenbergen JN, Nosanchuk JD: ‘Ready made’ virulence and ‘dual use’ virulence factors in pathogenic environmental fungi – the Cryptococcus neoformans paradigm. Curr Opin Microbiol 2003,6(4):332–337.CrossRefPubMed 16. Luo Y, Tucker SC, Casadevall A: Fc- and complement-receptor activation stimulates cell cycle progression of macrophage cells from G1 to S. J Immunol 2005,174(11):7226–7233.PubMed 17. Retini

C, Kozel TR, Pietrella D, Monari C, Bistoni F, Vecchiarelli A: Interdependency of interleukin-10 and interleukin-12 in regulation of T-cell differentiation and effector function Apoptosis inhibitor of monocytes in response to stimulation with Cryptococcus neoformans. Infect Immun 2001,69(10):6064–6073.CrossRefPubMed 18. Monari C, Baldelli F, Pietrella D, Retini C, Tascini C, Francisci D, Bistoni F, Vecchiarelli A: Monocyte dysfunction in patients with Ilomastat concentration acquired immunodeficiency syndrome (AIDS) versus Cryptococcus neoformans.

J Infect 1997,35(3):257–263.CrossRefPubMed 19. Levitz SM, Harrison TS, Tabuni A, Liu X: Chloroquine induces human mononuclear phagocytes to inhibit and kill Cryptococcus neoformans by a mechanism independent of iron deprivation. J Clin Invest 1997,100(6):1640–1646.CrossRefPubMed 20. Levitz SM, Nong SH, Seetoo KF, Harrison TS, Tolmetin Speizer RA, Simons ER: Cryptococcus neoformans resides in an acidic phagolysosome of human macrophages. Infect Immun 1999,67(2):885–890.PubMed 21. Zaragoza O, Alvarez M, Telzak A, Rivera J, Casadevall A: The relative susceptibility of mouse strains to pulmonary Cryptococcus neoformans infection is associated with pleiotropic differences in the immune response. Infect Immun 2007,75(6):2729–2739.CrossRefPubMed 22. Levitz SM, Farrell TP: Growth inhibition of Cryptococcus neoformans by cultured human monocytes: role of the capsule, opsonins, the culture surface, and cytokines. Infect Immun 1990,58(5):1201–1209.PubMed 23. Diamond RD, Bennett JE: Growth of Cryptococcus neoformans within human macrophages in vitro. Infect Immun 1973,7(2):231–236.PubMed 24.