Hatakka et al. studied the effect of Lactobacillus rhamnosus GG (LGG) on rheumatoid arthritis (RA) patients and reported an increase in serum IL-1 beta after LGG treatment with no significant change in IL-6, TNF-alpha, Myeloperoxidase (MPO), and IL-10.29 Conclusion A reduction in oxidative stress and cardiovascular risk factor seems to be an ideal treatment strategy in type 2 diabetic patients. The result of this study demonstrated that a 6 weeks oral treatment with probiotics decreased the concentration of TG,

MDA, and IL-6 level in type 2 diabetic patients; however the change were not statistically significant. These finding could warrant future studies to determine the therapeutic Inhibitors,research,lifescience,medical Inhibitors,research,lifescience,medical effects of probiotic on diabetic patients. Acknowledgment This study was a part of the M.S thesis by Abbas Yousefinejad. The authors acknowledge the financial support of Vice Chancellor for Research and Technology of Shiraz

University of Medical Sciences. Also we thank the staff members of Shiraz Endocrine and Metabolism Research Center for their valuable cooperation during this study. Conflict of interest: Inhibitors,research,lifescience,medical None declared
Background: In some cultures, including ours, direct explanation of inner psychic world is inhibited and stigmatized, therefore finding alternative modes of expression. The aim of this cross-sectional study was to assess the frequency of somatization in the depressed patients. Methods: The present study PF-02341066 cost comprised Inhibitors,research,lifescience,medical 500 patients referred to the outpatient clinic of Shiraz University of Medical Sciences, and diagnosed with major depressive disorders based on DSM-IV-TR. The presenting complaints of these patients were assessed through psychiatric interview. Inhibitors,research,lifescience,medical The presenting symptoms were divided into three main categories including mental symptoms, pain, and physical symptoms without

pain. Statistical analysis (chi-square and logistic regression) were performed to determine the relationship between presenting symptoms and some demographic variables such as age, gender, marital status, educational level and cultural background (urban or rural). Results: Physical symptoms other than pain, mental PDK4 symptoms, and pain were found in 193 (38.6%), 186 (37.2%), and in 121 (24.2%) patients respectively. Pain and physical complaints were more common in patients with rural cultural background, lower education, women and the married individuals. Headache (15.2%), irritability (10.6%) and pain in different parts of the body (10.4%) were the most frequent chief complaints of the patients. Hypochondriasis, suicidal idea, crying, irritability and insomnia were significant symptoms associated with the complaint of somatization. Conclusion: Somatic symptoms, especially pain, have a significant weight in the chief complaints of depressed patients.