Methods: Twenty GNS-1480 patients under general anesthesia during prone position were included in the study. The performed anesthesia method was the

same for all patients. Remifentanil was used for analgesia instead of nitrous oxide. MEPs were measured 5 times with a middle ear analyzer: before induction (BI), after intubation (AI), after turned to the prone position (PP1), at the end of the prone position (PP2), and after returned to the supine position (SP). Duration of prone position was also recorded.

Results: Of the 20 patients were 11 women and 9 men with a 49 +/- 13 mean age. BI-AI, AI-PP1, PP1-PP2, and PP2-SP comparisons of both MEPs were statistically significant (P < 0.0001). Right mean MEPs were BI, -1 +/- 23 daPa; AI, 41 +/- 51 daPa; PP1, 124 +/- 76 daPa; PP2, 152 +/- 59 daPa; and SP, 63 +/- 29 daPa; whereas left mean MEPs were BI, -24 +/- 55 daPa; AI, 28 +/- 34 daPa; PP1, 132 +/- 67 daPa; PP2, 162 +/- 48 daPa; and SP, 70 +/- 89 daPa. Significant increases were detected at the start and continuation of the prone position. The mean duration of prone position was 98 +/- 51 per minute.

Conclusions: The significant MEP increases during the prone position under general anesthesia depend on a number

of reasons. Among them are inhaler agents, pressure changes in mucosal blood vessels due to venous congestion, and the mastoid Screening Library bone volume. Further researches are required to determine and explain the mechanisms of PRT062607 molecular weight increase in MEP during prone position.”
“Nosocomial infections are the most important cause of morbidity and mortality among neonates and

mostly in infants admitted to neonatal intensive care units (NICU). The total number of neonates who develop nosocomial infections per admission varies from 6.2 to 30%. The role of nosocomial virus infections is generally neglected in the actual epidemiologic scenario mostly due to the lack of data in the medical literature. Based on a worldwide database of health care-associated outbreaks (http://www.outbreak-database.com) we performed an analysis of the incidence, type of pathogens and clinical features of neonatal viral outbreaks especially those reported in NICUs. We also describe, as an example of emerging virus in NICU, a Norovirus outbreak along with clinical presentation that varies from mild to moderate clinical symptoms like vomiting, gastric remainder, diarrhoea, abdominal distension or severe presentation like necrotizing enterocolitis. and measures implemented for terminating the outbreak. In conclusion, our study analyses the viral origins of nosocomial infections in NICU and underline that the role of viral agents in neonatal nosocomial infections needs to be further investigated even in diseases traditionally considered of bacterial origin like necrotizing enterocolitis.”
“Epigenetic medicine is still in its infancy.