Modern diagnostic methods are useful for the recognition of CNS complications in uremic patients. Data concerning visual evoked potentials (VEPs) of chronic renal failure (CRF) patients is limited.
Objective: In this study, we aimed to assess and compare VEPs abnormalities in CRF patients managed by only medical therapy (pre-dialysis) or medical therapy plus renal replacement therapy (continuous ambulatory peritoneal dialysis (CAPD) or hemodialysis (HD)).
Materials and methods: Fifty-nine patients diagnosed with CRF of various etiologies were divided into 3 groups according to the treatment
modalities used to manage CRF; pre-dialysis group, HD group and CAPD group. For the comparison of VEPs parameters, BMS202 in vivo an age matched control group was formed with 10 healthy subjects.
Results: Bilateral N2 latency (p<0.001), bilateral P2 latency (p=0.003), right N2 latency (p=0.006) and left VEP N2 latency (p=0.002) in the HD group was significantly higher than the control group. The CAPD group had significantly increased bilateral N2 latency (p<0.001), right eye VEP N2 latency (p=0.004), right eye P2 latency (p=0.001), left eye N2 latency (p=0.005) and left eye P2 latency (p=0.001) levels than the control group.
There was no significant difference between VEPs of the CAPD and HD groups.
Conclusion: The renal replacement treatments that we evaluated have similar effects on VEPs. Diminished VEPs indicating click here visual neuronal system damage were observed, when CRF progresses. CNS dysfunctions can be diagnosed and additional therapeutic approaches could be followed using VEPs during the treatment of CRF.”
“A 70% ethanol extract from the roots of Livistona chinensis has been investigated, led to the isolation of 18 compounds, including two new 6′-O-acyl-beta-D-glucosyl-beta-sitosterols, 6′-O-(2 ”-hydroxyheptadecanoyl)-beta-D-glucosyl-beta-sitosterol (1) and 6′-O-(icosa-9 ” Z,12 ” Z-dienoyl)-beta-D-glucosyl-beta-sitosterol (2), two new keto GKT137831 esters, ethyl 16-(dodeca-4”’ Z,7”’ Z-dienyl)-29-oxo-15-(tetradeca-5 ” Z,8 ” Z,11 ” Z-trienyl) triacontanoate (7), and 16-hydroxy-8-oxohexadecyl
tetradecanoate (9), a new unsaturated fatty acid, tetracosa-(11Z,14Z,18Z)-trienoic acid (8), as well as a new fatty alcohol, 10-decylnonadecane-1,19-diol (10). The structures of new compounds were elucidated, based on spectroscopic and chemical methods. The antiproliferative activity against four human tumor cell lines (K562, HL-60, HepG2, and CNE-1) was evaluated. Four compounds (1-3, 5) showed potent antiproliferative effects with the IC50 of 10-100 mu M. To our knowledge, this is the first report of the occurrence of 6′-O-acyl-beta-D-glucosyl-beta-sitosterol and 3-O-acyl-beta-sitosterol in the genus Livistona. Keto fatty acids and their esters are also rare in higher plant. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.