“
“Objective. This study aimed to systematically review the available literature on the treatment of patients with juvenile idiopathic arthritis (JIA) with temporomandibular joint (TMJ) involvement.

Study Design. According to the PRISMA statement (Preferred

Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, studies were included until JQ1 August 2012.

Results. A total of 40 articles were identified. TMJ involvement in patients with JIA varies between 17% and 87%. The mean age at diagnosis of JIA is 7.2 years. TMJ treatment can be divided into 2 main groups, an arthritis group and a dentofacial deformity group. The main treatment modalities are counseling, pharmaceutical interventions, physiotherapy, orthodontic treatment, surgery, or a combination of the

aforementioned therapies.

Conclusions. TMJ involvement in patients with JIA has a high incidence. There is no consensus on the treatment of TMJ pathology and dentofacial deformities in patients with JIA, and treatment varies from counseling to surgery. Treatment to improve aesthetics and function and to obtain pain reduction can be effective. However, the articles are Rigosertib heterogeneous, and the level of evidence is low (level IV).”
“OBJECTIVE: This study sought to identify the relationship between fibroblast telomerase expression, myofibroblasts, and telomerase-mediated regulatory signals in idiopathic pulmonary fibrosis.

METHODS: Thirty-four surgical lung biopsies, which had been obtained from patients with idiopathic pulmonary fibrosis and histologically classified as usual interstitial pneumonia, were examined. Immunohistochemistry was used to evaluate fibroblast telomerase expression, myofibroblast alpha-smooth muscle actin expression and the tissue expression of interleukin-4, transforming growth factor-beta, and basic fibroblast growth factor. The point-counting technique

MK-4827 mw was used to quantify the expression of these markers in unaffected, collapsed, mural fibrosis, and honeycombing areas. The results were correlated to patient survival.

RESULTS: Fibroblast telomerase expression and basic fibroblast growth factor tissue expression were higher in collapsed areas, whereas myofibroblast expression and interleukine-4 tissue expression were higher in areas of mural fibrosis. Transforming growth factor-beta expression was higher in collapsed, mural fibrosis and honeycombing areas in comparison to unaffected areas. Positive correlations were found between basic fibroblast growth factor tissue expression and fibroblast telomerase expression and between interleukin-4 tissue expression and myofibroblast alpha-smooth muscle actin expression. Negative correlations were observed between interleukin-4 expression and basic fibroblast growth factor tissue expression in areas of mural fibrosis.