Surgical attention must be given to the creation of fresh frozen specimen banks, as sensitivity of mutation detection may be higher in fresh frozen rather than paraffin embedded specimens.

The role of other mutations, such as K-RAS, predictive of response to EGFR inhibition with monoclonal antibodies in colon cancer, needs further investigation in these diseases. Future targeted therapy should take into account treatment regimens- as monotherapy or in combination with current chemotherapy. Acknowledgements Disclosure: The authors declare no conflict of interest.
Once peritoneal Sunitinib mouse metastases occur from gastrointestinal cancers or mesothelioma, morbidity and mortality are almost always secondary Inhibitors,research,lifescience,medical to disease progression within the abdominal cavity. Inhibitors,research,lifescience,medical Patients experience progressive abdominal distention due to tumor growth and malignant ascites, pain, early satiety, and ultimately experience profound cachexia and inanition (1). The condition is characterized grossly by diffuse tumor nodules on the peritoneal surfaces; the omentum is a favored site for development of extensive bulky metastases which is typically referred to as “omental caking” on preoperative imaging studies. Tissue is usually obtained by laparoscopic or percutaneous biopsy and the histologic features of the tumor combined with other clinical, laboratory, or imaging findings

can successfully identify Inhibitors,research,lifescience,medical the tumor site of origin. According to the multicenter EVOCAPE I study (2), the median survival in patients with peritoneal metastases was 5.2 months for those with advanced colorectal cancer (n=118) Inhibitors,research,lifescience,medical and 3.1 months for those with advanced gastric

cancer (n=125). Despite significant advances in the development of more efficacious Inhibitors,research,lifescience,medical systemic chemotherapy for many GI cancers, most notably colorectal cancer; systemic treatment is associated with potentially severe toxicity in many patients and median survival is still less than two years (Table 1). Mesothelioma is very rare with 200-400 new cases diagnosed annually in US, its incidence Sitaxentan is increasing and expected to reach a peak in 2020 in Europe (3). Table 1 Survival in patients with peritoneal dissemination secondary to various cancers based on variability in tumor biology Systemic chemotherapy for advanced GI cancers and mesothelioma It is important to briefly review the efficacy and toxicity of various systemic chemotherapy regimens commonly used for patients with advanced GI cancers or mesothelioma to provide context and better understand the potential role of cytoreduction surgery (CRS) and HIPEC. Over the past 6 years there have been several new chemotherapeutic and biological agents that have been approved by the FDA for treatment of patients with advanced colorectal cancer. One common regimen is 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) combined with bevacizumab. Saltz et al.