Antibody-dependent enhancement (ADE) is the process by which this website some virus-specific antibodies (generally speaking non-neutralizing antibodies) bind towards the virus and bind to some cells articulating FcR at first glance through their Fc section, therefore mediating the endocytosis and replication of this virus and improving the illness associated with the virus. This review summarized experience of ADE in breathing syncytial virus, dengue virus, influenza virus infection and explored the feasible process of COVID-19 high occurrence and extent of this disease, which implied difficulties in the act of vaccine development and offered some insights for COVID-19 pathogenesis.The COVID-19 pandemic reveals the flaws of present community health law system together with necessity of this amendment to Law on Prevention and Treatment of Infectious Diseases. The institutional design of this prevention and control of promising communicable condition shall be altered and Principle of Preventive Legislation shall be determined. After the multicultural coordination when you look at the pandemic prevention and control, the duties of the main and town will be clarified as well as the features for the experts additionally the general public need certainly to work totally and successfully. Present pandemic information launch system will be reformed to fix the dispute of legislation while the information direct system shall be optimized. Principle of proportionality shall be obeyed to guard the appropriateness, necessity and stability associated with pandemic prevention and control actions.Surgery is known as the core treatment plan for colorectal liver metastasis (CRLM), while its recurrence rate remains reasonably high, also for resectable CRLM. This suggestions that the efficacy of treatment involves not only technological elements of surgery, additionally biological behavior of cyst. For resectable CRLM, neoadjuvant treatment therapy is useful to get rid of the micro-metastasis, decrease postoperative recurrence price, display tumor biological behavior and enhance prognosis. But, questions about what sort of CRLM clients fits for neoadjuvant therapy and just what program should really be utilized are nevertheless debatable. This paper reviews stratified management of resectable CRLM, choice of neoadjuvant routine, particularly the application value of targeted therapy, on the basis of the most recent recommendations and scientific studies.Objective To investigate the security and feasibility of caudal-medial method coupled with “page-turning” middle lymphadenectomy into the laparoscopic right hemicolectomy. Techniques A descriptive cohort study was carried out. Medical data of 35 clients who underwent laparoscopic radical right hemicolectomy using caudal-medial approach along with “page-turning” middle lymphadenectomy at Department of Gastrointestinal procedure, Guangdong Hospital of Chinese Medicine from April 2018 to might 2020 had been retrospectively analyzed. All businesses had been carried out consecutively by the exact same doctor. The caudal-medial strategy was used to dissect suitable Toldt’s fascia therefore the anterior pancreaticoduodenal space autoimmune liver disease in a caudal-to-cranial and medial-to-lateral way guided by the duodenum. The “page-turning” middle lymphadenectomy ended up being cognitive biomarkers used to dissect the mesocolon over the superior mesenteric vein with ileocolic vein, Henle’s trunk and pancreas revealed preferentially. Results All the 35 customers finished the operation succes “page-turning” middle lymphadenectomy is safe and possible. The anterior pancreaticoduodenal space is preferentially mobilized, which reduces the issue of main vascular dissection.Objective To investigate the feasibility of transumbilical single-incision plus one interface (SIPOP) robotic total mesorectal excision. Methods medical information of a 70-year-old male patient with BMI 22.1 kg/m(2) which effectively underwent transumbilical single-incision plus 1 port robotic total mesorectal resection of upper rectal cancer tumors in the General procedure division of Daping Hospital of Army Military healthcare University on September 18, 2019 were retrospectively reviewed. Preoperative colonoscopy unveiled that the exact distance of upper rectal cancer to anal side had been 14 cm, while the tumor size was 2.5 cm×1.5 cm×1 cm. Pathological result confirmed rectal moderately classified adenocarcinoma. The preoperative abdominal CT showed thickened bowel-wall of upper colon therefore the blurred perirectal fat, recommending cyst infiltration. Outcomes The procedure had been successful. There have been no transformation to laparotomy or abdominal additional incision, together with mesorectum associated with specimen had been intact. The procedure time had been 165 mins, the loss of blood had been about 20 ml, and there have been no problems such problems for peripheral organs. Postoperative pathology revealed ulcerative moderately differentiated adenocarcinoma of the upper colon with TNM phase IVA (T4N2b). The postoperative data recovery had been smooth. Patient ambulated from the first time, the catheter had been eliminated regarding the 7th time, and discharged from the medical center in the 8th time. Conclusion The transumbilical SIPOP robotic total mesorectal excision is safe, efficient and possible.Objective To explore perhaps the cytoreductive surgery coupled with hyperthermic intraperitoneal chemotherapy (CRS+HIPEC) can increase the survival rate of colorectal cancer patients with peritoneal metastasis. Methods the appropriate studies were systematically retrieved from PubMed, Embase, Cochrane Library, CNKI, Wanfang, VIP database, while the research of French Elias’ team on peritoneal metastasis ended up being recovered manually. Inclusion criteria (1) The customers had been colorectal disease peritoneal metastasis. (2) there have been CRS+HIPEC remedies (therapy team) and other remedies (control team). (3) Survival analysis data of therapy group and control group had been available.