The method was validated as per the guidelines laid by ICH. The results of the validation tests were found to be satisfactory and therefore this method can be applied successfully to analyze drug formulations. ACKNOWLEDGMENT We would like to thank Macleods Pharmaceuticals add to favorites Ltd, Mumbai, India, for providing pure drug samples for this study and the Amrutvahini Sheti and Shikshan Vikas Sanstha, Sangamner, M.S., India, for providing us the research facility. Footnotes Source of Support: Nil Conflict of Interest: None declared.
Cefdinir is an advanced generation, broad / extended-spectrum oral semisynthetic cephalosporin.[1] The drug is an oral aminothiazolyl hydroxyimino cephalosporin. Cefdinir a broad spectrum cephalosporin is effective against enteric gram-positive and gram-negative bacteria.
Cefdinir is stable in the presence of some, but not all, ��-lactamase enzymes. As a result, many organisms are resistant to penicillins and some cephalosporins are susceptible to cefdinir.[2] It has been proven to be effective for common bacterial infections of the ear, sinus, throat, and skin.[3] Chemically, cefdinir [Figure 1] is [6R-[6��,7��(Z)]]-7-[[(2-amino-4-thiazolyl) (hydroxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. [4] Cefdinir is structurally similar to other oral (cefpodoxime proxetil, ceftibuten) or parenteral (cefepime, cefotaxime, ceftazidime, ceftriaxone) cephalosporins that contain an aminothiazolyl side chain at position 7 of the cephalosporin nucleus; however, cefdinir contains an unsubstituted oxime group rather than the methoxyimino group contained in many aminothiazolyl cephalosporins.
The oxime group may contribute to the improved activity against gram-positive bacteria. Similar to cefixime, cefdinir contains a vinyl moiety at position 3 of the cephalosporin nucleus, which makes the drug suitable for oral administration.[5�C6] The antibiotic has been approved for the treatment of community-acquired pneumonia, acute exacerbations of chronic bronchitis, acute maxillary sinusitis, treatment of respiratory and urinary tract infections, and for uncomplicated skin and skin structure infections. Thus, the third generation of cephalosporin is of great value in medical treatment due to its broad spectrum bactericidal effect.
Figure 1 Chemical structure of cefdinir A literature survey revealed that few analytical methods are available for the estimation of cefdinir from bulk drugs / dosage forms[7�C16] and from human plasma.[17] Anacetrapib The reported method for the estimation of cefdinir includes HPLC,[7�C11] the ultraviolet (UV) spectroscopic and colorimetric method,[12�C13] and the spectroflourimetric method of analysis.[14] There is also a liquid chromatography-tandem mass spectrometry (LCMS-MS) method reported for the estimation of cefdinir from human plasma.