The probability of hospitalization was significantly lower among TRC (34/446 or 7.6%) compared to DC (154/1,182 or 13.0%). Salmonellosis was the most common reason for hospitalization in both groups (12/34 TRC or 35.3% and 62/154 DC or ATR inhibitor 40.3%). TRC and DC were not statistically different by gender but they were by age and disease (Table 5). In comparison to DC, TRC had relatively more cases in the

15- to 24-year-age group (18.8% vs 10.4%) and less in the 60+ year age group (9.6% vs 13.7%). More than 33% of the total cases were TRC for 6 of the 12 reportable diseases included in the study: amebiasis, cyclosporiasis, giardiasis, hepatitis A, shigellosis, and typhoid and paratyphoid fever. The criterion for disease-specific comparisons (30 or more TRC) was met for Campylobacter enteritis, giardiasis, and non-typhoidal salmonellosis. Among the Campylobacter enteritis cases, Campylobacter coli was statistically more

common among TRC (71% of all C coli cases) and Campylobacter jejuni was less common (20% of all C jejuni cases). Salmonella enteritidis (SE) was the most frequent serotype overall and was significantly GSK1120212 chemical structure more commonly found in TRC (57/117 or 48.72%) compared to all other serotypes combined (58/315 or 18.4%). TRC were younger than DC for giardiasis and campylobacteriosis, but not for non-typhoidal salmonellosis. The delay between onset and report was statistically longer among TRC compared to DC for Campylobacter enteritis (interquartiles: 7-10-17 and 6-8-11 Edoxaban d, respectively) and non-typhoidal salmonellosis (8-10.5-18 and 6-8-11 d, respectively), but not for giardiasis. For each disease, the duration of disease and percent hospitalized did not differ between TRC and DC. Comparisons of symptoms between TRC and DC among each disease showed only one statistically significant difference: bloody diarrhea was more frequent in DC compared to TRC among Campylobacter enteritis (40% vs 20%, respectively). This study clearly fulfills gaps identified with regard to travel-acquired enteric illness in Canada.14

It comprehensively describes TRC among 10 reportable diseases caused by enteropathogens in a Canadian community. The study also provides evidence of particular traveler profiles based on travel characteristics and age and indicates potential profile-associated risk in contracting illness abroad. Finally, it quantifies the burden of TRC in terms of cases and hospitalization. This study used surveillance data, which is one possible approach identified to estimate health risk related to travel outside the country of residence.24 More specifically, data were obtained through a sentinel site surveillance approach, demonstrating its efficiency compared to the other surveillance approaches currently in place in Canada.