The total operative time was 191 (130-280) min while laparoscopic part was 62 (40-105) min. The mean blood loss was 261 (150-400) ml. Postoperative blood pressure returned to normal in five patients but two others required single-agent antihypertensive medication. Minor complications included lumbar artery injury and flank pain each in one case. The anastomosis was patent in all patients

and no re-stenosis occurred during 6-40 months of follow-up.

Conclusions: Hybrid laparoscopic techniques involving renal artery dissection and hypogastric artery harvesting are feasible in surgical MLN2238 research buy treatment of Takayasu renal arteritis. This hybrid surgical technique provides an alternative approach to revascularise the renal circulation, especially for the patients of PTA treatment failure. (C) 2011 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.”
“The diverse abilities of cerium oxide nanoparticles (CONPs) have encouraged researchers to pursue CONPs as a therapeutic agent to treat a number of diseases, including cancer. In vitro and in vivo studies have shown CONPs to be toxic to cancer cells, inhibit invasion, and sensitize cancer cells to radiation therapy. selleck screening library However, CONPs display minimal toxicity

to normal tissues and provide protection from various forms of reactive oxygen species (ROS) generation. The antioxidant capabilities of CONPs, which enable radiation protection, have also resulted in the exploration of these particles as a potential treatment for other disorders characterized by ROS accumulation, such as diabetes and macular degeneration. While critical information regarding the uptake, retention, and clearance of these particles is incomplete and conflicting reports exist about in vitro toxicity, most research into the various applications of CONPs has yielded promising data. This review highlights the current research into cerium oxide nanoparticles as a novel therapeutic for the treatment of cancer and other diseases.”
“Production

of lipopeptides fengycin and surfactin in rotating discs bioreactor was studied. The effects of rotation velocity and the addition of agitators between the discs on volumetric oxygen transfer find more coefficient k (L) a were firstly studied in model media. Then the production of lipopeptides was also studied at different agitation conditions in the modified bioreactor (with agitators). The effect of agitation on dissolved oxygen, on submerged and immobilized biomass, on lipopeptide concentrations and yields and on the selectivity of the bioreaction was elucidated and discussed. The proposed modified rotating discs bioreactor allowed to obtain high fengycin concentrations (up to 787 mg L-1), but also better selectivity of the bioreaction towards fengycin (up to 88 %) and better yields of fengycin per glucose (up to 62.9 mg g(-1)), lipopeptides per glucose (up to 71.