, 2000, Chassin et al., 2005, Cleveland et al., 2005, Harakeh et al., 2004 and Lac et al., 2009). What is interesting, however, is that we found substance-specific main effects. While regular alcohol use was more common in adolescents that perceived their parents as overprotective, the risk of cannabis S3I-201 manufacturer use was enhanced by parental rejection and buffered by emotional warmth. Apparently, being blocked in the pursuit of autonomy (indicated by overprotection) is more likely to result in alcohol consumption, whereas a family environment characterized

by rejection and little warmth places an adolescent at risk for future cannabis use. We suggest that these substance-specific associations might be explained by distinct reactions to the different parenting behaviors in combination with higher parental permissiveness towards

alcohol versus cannabis use. More specifically, children of overprotective parents might more easily react to the restrictive behavior of their parents by using alcohol rather than cannabis, keeping thereby closer within the substance use boundaries defined by their overprotective parents. In contrast, adolescents that feel rejected by their parents might feel less restricted by parental rules that prohibit the use of cannabis, and might be more likely to use cannabis in their search for acceptance by peers. Finally, adolescents that experience a warm relationship Pazopanib with their parents may be more likely to adopt parental rules, which are expected to be less permissive towards cannabis use when compared to alcohol use. It should be noted, however, that the absence of an association between parental warmth and regular alcohol use contrasts previous findings of a negative relation between indicators of parental only warmth or support and adolescent

alcohol use (Barnes et al., 2000 and Cleveland et al., 2005). An additional consideration is that, instead of affecting the risk of regular substance, parenting behavior might also be influenced by a child’s problem behavior (O’Connor, 2002), including (early onset of) substance use. Since relatively little research is available on parenting in relation to illicit substance use, and on the specific role of parenting across different classes of substances, we recommend future research in this area. Such research might address the interplay between parenting and more proximal risk factors, such as affiliation with deviant or substance-using peers, which may further explain the relationship between parenting behaviors and adolescent substance use. In addition, given that some parenting behaviors are subject to change during adolescent development (Laird et al., 2009) and in reaction to the behavior of the child (O’Connor, 2002), we recommend future studies to focus on the change in parenting behaviors during adolescence and on the interplay between parenting and child characteristics.