4%, 5 17% vs. 3 (0.072) 9% vs. 6% 0 vs. 11% LACT, 66.3%, 10 17% vs. 15% 25% vs. 6% (0.082) 5% vs. 20% LACT, 74.2%, 3 0% vs. 8% 0% vs. 9% 6% vs. 0% (0.023) LACT, 83.1%, 4 9% vs. 0% 0% vs. 6% 0% vs. 4% LACT, 84.7%, 40 65% vs. 59% 59% vs. 66% 74% vs. 58% LACT, 86.6%, 3 0% vs. 8% 0% vs. 9% 16% vs. 0% (0.023) LACT, 92.3%, 8 4% vs. 18% 6% vs. 19% 32% vs. 4% (0.007) EREC 4.8%, n = 13 22% vs. 20% 34% vs. 6% (0.011) 5% vs. 27% EREC 35.3%, 8 26% vs. 5% (0.048) 16% vs. 9% 5% vs. 16% EREC, 39.7%, 9 26% vs. 5% (0.022) 16% vs. 13% 0% vs. 20% (0.048) EREC, 46.9%, 19 52% vs. 18% (0.004) 31% vs. 28% 11% vs. 38% (0.004) EREC, 50.9%, 34 70% vs. 43% (0.021) 53% vs. 53% 37% vs. 60% EREC, 61.1%, 18 43%

vs. 20% (0.044) 22% vs. 34% 32% vs. 27% EREC, Citarinostat 73.9%, 28 61% vs. 35% (0.043) 44% vs. 44% 37% vs. 47% CLEPT, 11.9%, 31 22% vs. 63% (0.002) 47% vs. 50% 63% vs. 42% CLEPT, 15.4%, 8 22% vs. 8% (0.048) 6% vs. 19% 5% vs. 16% CLEPT, 16.0%, 6 26% vs. 0% (0.002) 16% vs. 3% 0% vs. 13% CLEPT, 20.5%, 9 26% vs.8% (0.022) 13% vs. 16% 5% vs. 18% CLEPT, 38.8%, 8 22% vs. 8% (0.048) Fosbretabulin chemical structure 16% vs. 8% 0% vs. 18% CLEPT, 52.1%, 8 4% vs. 18% 9% vs. 16% 26% vs. 7% (0.044) CLEPT, 67.9%, 12 30% vs. 13% (0.048) 13% vs. 25% 11% vs. 22% CLEPT, 84.0%, 7 0% vs. 18% (0.037) 6% vs. 16% 26% vs. 4% (0.021) BFRA, 5.0%,

5 21% vs. 0% (0.008) 6% vs. 9% 0% vs. 11% BFRA, 9.9%, 10 21% vs. 13% 26% vs. 6% (0.043) 5% vs. 20% BFRA, 21.5%, 9 25% vs. 10% (0.023) 6% vs. 22% 11% vs. 16% BFRA, 36.8%, 7 0% vs. 18% (0.036) 10% vs. 13% 21%

vs. 7% BFRA, 62.8%, 5 0% vs. 13% 3% vs. 13% 21% vs. 2% (0.026) BIFI, 26.6%, 40 59% vs. 77% 62% vs. 79% 94% vs. 61% (0.022) *The DGGE analysis was performed by applying universal bacterial primers (UNIV) and specific primers for the lactic acid bacteria (LACT), Eubacterium rectale – Clostridium coccoides group (EREC), Clostridium leptum group (CLEPT), Bacteroides fragilis group (BFRA) and Bifidobacterium spp. (BIFI). **Detection frequencies (% of samples positive) of the specified DGGE genotypes are presented. Statistical analysis: The Fisher’s exact test based on band presence/absence data. P-values for the statistically significant differences are presented in parenthesis. Figure 5 Abundance of bifidobacteria in ABO blood groups. a) Total bifidobacteria counts (copies/g faeces: average ± SD) Staurosporine purchase by bifidobacteria species and genus specific qPCR-analysis. b) Detection frequencies (% of samples positive) of bifidobacteria as determined with the Bifidobacterium genus and species specific qPCR analysis.