We also demonstrated 1) upregulation of tumor-suppressing transcriptional factors, the noncoding microRNA-638 and microRNA-923, and 2) downregulation of proteins associated with Daporinad clinical trial the PI3K/PI3K/AKT signaling pathway in bostrycin-treated cells, suggesting that bostrycin may be a new PI3K/AKT signal pathway-targeting drug for the treatment of pulmonary adenocarcinoma. Conflict of interests The authors declare that
they have no competing interests. Acknowledgements This work was supported by grants from The Natural Science Funds of Guangdong Province (7001646), and the Science and Technology Project of Guangdong Province (2008B080703022). We thank the Marine Microorganism Laboratory, Institute of Chemistry and Chemical Engineering, Sun Yat-Sen University, for kindly providing the test compound, bostrycin; the Electron Microscope Center, North School Region, Sun Yat-Sen University, for the technical support with the electron microscope; Hangzhou Lianchuan Biological Message Ltd. Company for the technical support in gene chip and real-time RT-PCR techniques; and Dr. Tan Li (The Affiliated Tumor Research Centre of Sun
Yat-Sen University) for the advice on western blotting. Electronic supplementary material Additional file 1: Figure S1, Bostrycin (hydroxy-methoxy-tetrahydro-5-methyl anthracene dione). The file contains the molecular chemical structure of bostrycin. (TIFF 44 KB) References 1. Hodkinson ALK phosphorylation PS, Mackinnon A, Sethi T: Targeting Growth Factors in Lung Cancer. Chest 2008,133(5):1209–1216.PubMedCrossRef 2. Mayer AM, Gustafson KR: Marine pharmacology in 2005–2006: antitumour and cytotoxic compounds. Eur J Cancer 2008, 44:2357–2387.PubMedCrossRef 3. Lin W, Fang LK, Liu JW, Cheng WQ, Yun M, Yang HL: Inhibitory effects of marine fungal metabolites from the South China Sea on prostate cancer cell line DU-145. International Journal of Internal Medicine 2008, 35:562–564. 4. Chen CQ, Fang LK, Liu JW, Zhang JW, Yang GG, Yang W: Effects of marine fungal metabolites (1386A) from SPTLC1 the South China Sea on proliferation,
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