Conclusions. The Nepicastat inhibitor HRQoL questionnaire can be used in evaluating QoL in PBS/IC patients. Treatment of PBS/IC had obvious effects on QoL.”
“Calotropis gigantea (Linn.) R.Br. (Asclepiadaceae), commonly known as milkweed or swallow-wort, is found chiefly in wasteland throughout India. It has been reported as a traditional folkloric medicine in treatment of asthma in the Indian literature. Roots containing a-and beta-amyrin are reported to possess anti-lipoxygenase activity. Hence, our objective was to evaluate the effect of the methanolic extract of Calotropis gigantea (CG) root on egg albumin induced

passive paw anaphylaxis and compound 48/80 induced mast cell degranulation in rats. CG were given at doses of 100, 200, 400 mg/kg, p.o., to rats. We found that CG significantly increases percentage inhibition of paw edema volume at all doses but shows significant percentage protection of the mast cells at 400 mg/kg. p.o., to rats. Hence, the present investigation confirm the use of CG as anti-anaphylactic and mast cell stabilizing in treatment of asthma.”
“Objective. To retrospectively evaluate the effects selleck inhibitor of intermittent self-dilatation (ISD) on the natural course of urethral strictures after an internal urethrotomy. Material and methods. A retrospective case-control analysis of all males who had undergone a first time internal

urethrotomy due to a urethral stricture in 1998-2000 at 15 urological departments in Sweden. Out of 217 included patients 162 were treated with internal urethrotomy only and 55 with internal urethrotomy followed by postoperative ISD. Demographic data including

stricture localization, stricture aetiology and reoperation dates, as well as postoperative indwelling catheter and antibiotic treatment, were collected from the medical records. Factors concerning the ISD were also gathered: postoperative starting time, dilatation catheter size, dilatation find more frequency and time for retreatment. All patients’ medical records were followed for 3-6 years until 2003. Results. The median time until recurrence (surgical reoperation) was 732 days in the ISD group and 167 days in the non-ISD group (p0.0001). The frequency of recurrence after internal urethrotomy was 9% (5/55) in the ISD group and 31% in the non-ISD group (51/162) during the observational follow-up period (p=0.0007). There was a higher risk of recurrence among those with a traumatic aetiology (39/104) compared with those with unknown aetiology (14/89) (p=0.0005). Patients with a postoperative catheter had a lower risk of recurrence (40/172) than those without one (16/45) (p=0.01). Conclusions. Postoperative ISD of a urethral stricture, primarily treated by internal urethrotomy, significantly reduces the stricture recurrence rate as well as delaying the time until recurrence.