Given that the omics-based technologies are oblivious to changes that only learn more occur in minor cellular subsets we validated the proteomic data using IHC, which provides protein expression information with a valuable topological
component. Besides confirming the omics-derived data, the IHC analysis revealed that in two cases the ALN metastases may have been derived from a distinct minor cell subpopulation present in the primary tumor rather than from the bulk of it.”
“Over the last decade considerable research effort has been invested in an attempt to understand the dynamics of viruses as they spread through complex networks, be they the networks in human population, computers or otherwise. The efforts have
contributed to an understanding of epidemic behavior in random networks, but were generally unable to accommodate specific nonrandom features of the network’s actual topology. Recently, though still in the context of the mean field theory, Chakrabarti et al. (2008) proposed a model that intended to take into account the graph’s specific topology and solve a longstanding problem regarding epidemic thresholds in both random and nonrandom networks. Here we review previous theoretical work dealing with this problem (usually based on mean field approximations) and show with several relevant and concrete
counter examples that results to date breakdown for nonrandom click here topologies. (C) 2011 Elsevier Ltd. All rights Cyclopamine mouse reserved.”
“Migration of hematopoietic stem cells (HSCs) is essential during embryonic development and throughout adult life. During embryogenesis, trafficking of HSCs is responsible for the sequential colonization of different hematopoietic organs by blood-producing cells. In adulthood, circulation of HSCs maintains homeostasis of the hematopoietic system and participates in innate immune responses. HSC trafficking is also crucial in clinical settings such as bone marrow (BM) and stem cell transplantation. This review provides an overview of the molecular and cellular signals that control and fine-tune trafficking of HSCs and hematopoietic progenitor cells in embryogenesis and during postnatal life. We also discuss the potential clinical utility of therapeutic approaches to modulate HSC trafficking in patients.”
“The dopamine receptor genes have been implicated in the pathogenesis of schizophrenia, but definitive evidence of association is still lacking. To identify whether functional variants of the D2-like receptors (DRD2, DRD3 and DRD4) confer risk of schizophrenia, we conducted a two-stage association study.