In the 18th century, opium’s addictive potential was recognized when a large number of Chinese people became addicted, and the Chinese government tried to suppress its sale and use. In Europe, the working classes were threatened by alcoholism.16 At that time, psychiatry had matured into a scientific discipline,

established nosological classifications, and taken stands on societal issues. The American physician Benjamin Rush, writing in the 18th century, maintained that compulsive drinking was characterized by a loss of self-control, and that the disease was primarily attributable to Inhibitors,research,lifescience,medical the drink itself and not the drinker. His remarks concerned only strong liquors; wine and beer, in his view, were salutary thirstquenchers.17 In German-speaking countries, the most influential physician was Constantin von Brühl-Cramer, who is credited with coining the term “dipsomania” (“Über die Trunksucht und eine rationelle Heilmethode derselben” [1819]). Dedicated medical journals were Inhibitors,research,lifescience,medical created in the 19th century. The Journal of Inebriety appeared in the United States in 1876, while the British Journal of Addiction was first published in 1884. Emil Kraepelin, the physician Inhibitors,research,lifescience,medical who exerted the greatest influence

on the shaping of modern psychiatry, fought alcohol with extreme dedication.18 He published the first psychometric data on the influence of tea and alcohol in the early 1890s. As a result of his research, he came to the conclusion that chronic alcoholism provoked cortical brain lesions that led to a permanent cognitive Inhibitors,research,lifescience,medical decline. Drawing from personal consequences, Kraepelin became a teetotaler in 1895. Before that, he had been a moderate drinker, recognizing alcohol’s relaxing and mood-elevating effects, as in this letter to the psychiatrist August Forel in December 1891: Inhibitors,research,lifescience,medical “…I have often found that, after great exertion, and also after severe mood depression, alcohol has had a clearly beneficial effect on me….”19 Kraepelin was particularly concerned about the social and genetic

consequences of alcohol. Sigmund Freud, a contemporary of Kraepelin, laid the ground for the psychological approach to addiction. Freud wrote in a letter to Fliess in 1897: “…it has dawned on me that masturbation is the one major habit, the ”primal“ addiction and that it is only Ketanserin as a substitute and replacement for it that the other addictions – for alcohol, morphine, tobacco, etc – come into existence.”20 A Microtubule Associated inhibitor consequence of the psychological approach is that the addiction to different substances (alcohol, opiates, etc) and even to certain types of behavlor, such as gambling, have been gathered together under a common denominator, and regarded as different expressions of a single underlying syndrome. Interestingly, the Qur’an warns against both wine (khamr) and gambling (maisir) in the same sura (2,219).