Figure 2 Electrochemical characters. Nyquist plots (a) and Tafel polarization curves (b) of DSSCs based on PEDOT/FTO CE, TiO2-PEDOT:PSS/PEDOT:PSS/glass CE, and Pt/FTO CE. Table 1 Electrochemical impedance spectra (EIS) parameters of PEDOT/FTO CE, TiO 2 -PEDOT:PSS/PEDOT:PSS/glass CE, and Pt/FTO CE Counter electrode R s (Ω

cm2) R ct (Ω cm2) Z W1 (Ω cm2) PEDOT:PSS/FTO 4.22 4.47 11.28 TiO2-PEDOT:PSS/PEDOT:PSS/glass 23.26 1.51 4.02 Pt/FTO 4.91 5.73 – Furthermore, Tafel polarization curves LDN-193189 were carried out on the same dummy cells used in EIS measurement to investigate the interfacial charge transfer properties of CE/electrolyte, and the corresponding results are shown in Figure 2b. The exchange current (J 0) = 0.58 mA, calculated from the intersection of the linear cathodic and anodic Tafel polarization curves [16, 21], was derived from the TiO2-PEDOT:PSS/PEDOT:PSS/glass composite film and higher than that of PEDOT:PSS/FTO film (0.14 mA). Correspondingly, the catalytic activity of TiO2-PEDOT:PSS/PEDOT:PSS/glass composite CE is much higher than that of PEDOT:PSS/glass CE, which demonstrates that the big surface area of TiO2 nanoparticles enhances the reduction of I3 − to I− remarkably. Though the J 0 of TiO2-PEDOT:PSS/PEDOT:PSS/glass composite CE is smaller than that of Selleckchem PCI32765 Pt/FTO CE (1.2 mA), the former still exhibits superior catalytic activity and has great

potential to act as CE for DSSC. Figure 3 presents the photocurrent density-voltage (J-V)

curves of DSSCs using PEDOT:PSS/FTO CE, TiO2-PEDOT:PSS/PEDOT:PSS/glass CE, and Pt/FTO CE, GBA3 respectively, and the related photovolatic parameters are shown in Table 2. There is Foretinib research buy little difference in V oc values of these three cells. The FF of the DSSC with PEDOT:PSS/FTO CE is just 0.43 because of the poor catalytic activity of PEDOT:PSS solution. After modified by the TiO2 nanoparticles, the DSSC with TiO2-PEDOT:PSS/PEDOT:PSS/glass CE has obtained higher FF of 0.51 and thus higher η = 4.67% (increasing 22% compared with 3.64% for the DSSC with PEDOT:PSS/FTO CE). This is mainly due to the reduced charge transfer resistance and porous diffusion impedance because of the large electrochemical surface area in the porous TiO2-PEDOT:PSS layer. Compared with DSSC based on Pt/FTO CE, the one with TiO2-PEDOT:PSS/PEDOT:PSS/glass CE has lower FF, but its overall efficiency has already reached 91.39% of the one with Pt/FTO CE. It is noticeable that the performance of TiO2-PEDOT:PSS/PEDOT:PSS layers can befurther enhanced by optimazation of their weight ratio and the film thicknesses, referring to the previous studies using TiO2-PEDOT:PSS/FTO CE [22]. With such an excellent performance, the TiO2-PEDOT:PSS/PEDOT:PSS/glass CE has great potential to be a substitute for Pt- and FTO-based CEs which are very expensive and account for a large part of the cost.

Figure 1a shows that the reflection peaks of (100), (002), and (101) correspond to hexagonal ZnO with a wurtzite structure, but a preferred orientation along the (002) plane is intense. The diffraction peaks at 2θ = 34.55° owing to the dominant (002) GaN peak, 2θ = 32.39° owing to the GaN (100) peak, and 2θ = 36.86° owing to the GaN (101) peak could be observed in GaN/Si films as shown in Figure 1b. We noticed that the diffraction peak of (100) and (101) is significantly

obvious as shown in Figure 1a,b. The reason is that the incline columnar grains are presented as shown in Figure 2a,b, and some ZnO and GaN nanostructures are not perpendicular to the substrate and partially exposed the (100) and (101) planes to the X-ray. Therefore, the diffraction intensity from the (100) and (101) planes is also rather strong in comparison with that of the other main planes, e.g., (110). Figure S63845 supplier 1 XRD spectra. ZnO films deposited on different substrates at 400°C: (a) Si substrate and (c) GaN/Si substrate. (b) Annealed

GaN thin films deposited on Si substrate. Figure 2 SEM images. ZnO films deposited A-1210477 supplier on different substrates: (a) Si substrate and (c) GaN/Si substrate. (b) Annealed GaN thin films deposited on Si substrate at 800°C. (d) The cross-sectional images of the ZnO nanostructure on GaN/Si (111) substrates. (e) EDX spectrum of ZnO nanostructure derived from (c). XRD peaks of ZnO films grown on GaN/Si substrate show merely (002) orientation, and an obvious promotion of crystalline quality of ZnO thin film grown on GaN/Si substrate can be obtained. Moreover, the (002) positions of ZnO and GaN show that the ZnO has very similar c-axis lattice parameter with GaN. The XRD pattern indicates that the growth direction of ZnO/GaN/Si is [002], and the orientation relationship with GaN

ASK1 epilayer is [002]ZnO//[002]GaN. This implies that ZnO (002) plane is synthesized parallel to the basal plane of the GaN epitaxial layer substrate. SEM observation Figure 2a,b,c shows the SEM photographs of ZnO/Si films, GaN/Si films, and ZnO/GaN/Si films. Large and uneven grains are distributed on the ZnO surface for the thin film grown on Si (111) substrate as shown in Figure 2a. In Figure 2b, the incline columnar GaN structure annealed on the Si (111) substrate is presented. Besides, the obvious CA-4948 increase of crystalline grain with the hexagonal ZnO wurtzite structure is observed in Figure 2c; the incline columnar growth on the Si (111) substrate is transformed into a nanoflower grain on GaN/Si (111) template as shown in Figure 2c. Figure 2c illustrates that the surface property of ZnO/GaN/Si thin film is improved, and the thin film becomes more even than ZnO/Si film. It demonstrates that the quality of ZnO thin film was improved due to epitaxial growth of crystalline grain by GaN epitaxial layer.

Nucleotide sequence accession number ALB1, AYG1, ARP1, ARP2, ABR1 and ABR2 gene sequences determined for strains or isolates CBS 113.26, IHEM 18963, IHEM 2508, IHEM 9860 and IHEM 15998 were deposited in the Genbank selleck compound database and are available under accession numbers FJ406463 to FJ406498 (see Table 2). Scanning electron microscopy Cultures grown through dialysis membranes, conidial suspensions,

and conidia fixed on laminin-coated glass coverslips, were examined by SEM. Conidial suspensions were prepared as previously described. For the observation of conidial heads, cultures were grown on YPDA plates through sterile dialysis membranes. After 24 hours incubation, the membrane was TPX-0005 in vitro removed from the agar plate and then cut into squares (0.5 cm × 0.5 cm) at the periphery of the colony. Round glass coverslips (12 mm diameter) were coated with 500

μL of a laminin solution (10 μg/mL final concentration) in phosphate buffered saline 0.15 M pH 7.2 (PBS) supplemented with 10 mM ethylene-diamine-tetraacetic acid (EDTA) to prevent polymerization of laminin. After 30 min incubation at 37°C under constant shaking, coverslips were washed in PBS. They were then directly applied to the surface of sporulating cultures, and finally washed to remove non adherent conidia. All samples were fixed with a mix of 2% glutaraldehyde and 2% paraformaldehyde in phosphate buffer 0.1 M under vacuum for 24 hours. After washing, the cells were post-fixed with 2% osmium tetroxyde, then dehydrated by passage through ethanol solutions of increasing concentration (50 to 100%). Finally, ethanol was replaced with LBH589 hexamethyldisilazane (HMDS) and samples were coated with carbon. Observations were made on a JSM 6301F scanning electron microscope (Jeol, Paris, France) operating at 3 kV and equipped with digital imaging. Flow cytometry analysis Human plasma fibronectin and laminin

from the murine Englebreth-Holm-Swarm sarcoma tumour (Sigma-Aldrich) were labelled with 5-fluorescein isothiocyanate (FITC; Sigma-Aldrich) by a procedure adapted from Clark and Shepard [31], as previously described [30]. Binding of laminin and fibronectin Gefitinib datasheet to the conidia was analysed by flow cytometry as described previously for A. fumigatus . In these assays, 107 conidia were incubated for 30 min at 37°C under constant shaking with 250 μL of FITC-conjugated protein solution (50 μg/mL final concentration). The cells were then washed, pelleted by centrifugation (3 min at 3500 g) and fixed with 1% formaldehyde in PBS. Experiments were performed in PBS (supplemented with 10 mM EDTA for laminin binding assays). SpecifiCity of the binding was assessed by incubating the cells with the fluorescent laminin or fibronectin in the presence of a 10-fold excess of the same unlabeled protein. All experiments were carried out at least twice and included a negative control performed by incubating the cells with no ligand to ascertain the absence of autofluorescence.

Liver 1991, 11:100–105.PubMed 8. Roskams T, Desmet V: Embryology of extra- and intrahepatic bile ducts, the ductal plate. Anat Rec (Hoboken). 2008,291(6):628–635. 9. Geerts A: History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells. Semin Liver Dis 2001, 21:311–335.CrossRefPubMed 10. Cassiman D, Barlow A, Borght S, Libbrecht L, Pachnis V: Hepatic stellate cells do not derive from neural crest. J Hepatol 2006, 44:1098–1104.CrossRefPubMed 11. Clotmann F, Libbrecht L, Gresh

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Because HS and LA had a significant association (see “Results” section), we ran two models for each dependent variable: one model with GR, HS, and their interaction, and one model with GR, LA, and their interaction. Results All seven types of rarity were represented in this dataset, and dense, generalist (common) species were not included

(Fig. 1). Species type SGD (small GR, generalist HS, and dense LA) was the least replicated with only three species. The most replicated rarity type in the dataset was SSS (small GR, specialist, sparse LA) with N = 30. Within each descriptor variable type (pollination syndrome, dispersal vector, mating system), each category is reasonably well replicated (Table 1), although the limited degree to which species were completely described was BIX 1294 mw apparent, with total N for each descriptor variable between 52 and 67. Species with small GRs had similar degrees of HS and LA as rare species with large GRs. AC220 Habitat requirement was not independent from LA (Table 2): a greater proportion of generalist species were locally sparse (sparse:dense ratio 7:1, data not shown). This is an expected result, given the emphasis on rarity within the dataset

(see “Discussion” section). Table 2 Results of contingency analysis for association among rarity axes Source Geographic range (GR) Habitat specificity (HS) Geographic range (GR) – – Habitat specificity (HS) 6.586 Tubastatin A molecular weight , 0.010 – Local abundance (LA) 1.569, 0.120 0.022, 0.881 Degrees of freedom for each variable are equal to one. χ2 statistic for each association is first, followed by the P-value 3-mercaptopyruvate sulfurtransferase in italics. Significant p-values (below 0.07) are in bold There was a significant

difference in dispersal mechanism between rare species of large and small GR (Table 3). Species with small GR were far more likely to have abiotic dispersal (abiotic:biotic ratio 3:1, Fig. 2). Species of large GR had no difference in dispersal vector (Fisher’s exact test, P > 0.9). Although the sample sizes of disperser identity are too small for analysis, the data are presented in Table 4. All ant- and ballistic/gravity-dispersed species in this dataset have small GRs, and no species with small GR is water-dispersed. Table 3 Results of logistic regression for GR, HS, and LA Source Nparm DF χ2 Prob > χ2 Geographic range (GR)  Pollination 1 1 1.726 0.462  Dispersal 1 1 7.329 0.007  Mating system 2 2 2.911 0.233 Habitat specificity (HS)  Pollination 1 1 0.273 0.602  Dispersal 1 1 0.055 0.815  Mating system 2 2 0.692 0.708 Local abundance (LA)  Pollination 1 1 2.295 0.130  Dispersal 1 1 2.169 0.141  Mating system 2 2 3.383 0.184 Significant P-values (below 0.05) are in bold Fig. 2 Frequency of species with each type of dispersal vector (abiotic or biotic) within each GR (small or large). Species with small GR are more likely to have an abiotic seed dispersal vector (Fisher’s exact test, P = 0.

PubMedCrossRef 52. Hough CD, Cho KR, Zonderman AB, et al.: Coordinately up-regulated genes in ovarian cancer. Cancer Res 2001, 61:3869–3876.PubMed 53. Tsuda H, Ito YM, Ohashi Y, et al.: Identification of overexpression and amplification PD-0332991 research buy of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses. Clin Cancer Res 2005, 11:6880–6888.PubMedCrossRef 54. Schwartz DR, Kardia SL, Shedden KA, et al.: Gene expression in ovarian

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Temsirolimus, Carboplatin, and Paclitaxel as First-Line Therapy in Treating Patients With Newly Diagnosed Stage III or Stage IV Clear Cell Ovarian Cance. http://​clinicaltrials.​gov/​ct2/​show/​NCT01196429, accessed on April 16, 2012 61. Sunitinib Malate in Treating Patients With Persistent or Recurrent Clear Cell Ovarian Cancer. http://​clinicaltrials.​gov/​ct2/​show/​NCT00979992: accessed on April 16, 2012 Competing SBI-0206965 chemical structure interests The authors declare that they have no competing interests. Authors’ contributions Dr Takano and Dr Tsuda wrote the manuscript. Protirelin Dr Takano, Dr Tsuda, and Dr Sugiyama approved it. All authors read and approved the final manuscript.”
“Introduction Antipsychotics are common in the treatment of schizophrenia, affective disorders, organic psychosis, and dementia [1, 2]. The side effects associated with antipsychotic use include sedation, extrapyramidal symptoms (EPS), and orthostatic hypertension, all of which may increase the risk of falls, especially during the initial period of exposure [3]. Conventional antipsychotics (e.g., haloperidol, chlorpromazine) and the atypical antipsychotic risperidone at high dose have a high affinity for dopamine D2 receptors [4].

PubMedCrossRef 8. Li PL, Hwang I, Miyagi H, True H, Farrand SK: Essential components of the Ti plasmid trb system, a type IV macromolecular transporter. J Bacteriol 1999,181(16):5033–5041.PubMed

EPZ5676 manufacturer 9. Christie PJ: Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines. Mol Microbiol 2001,40(2):294–305.PubMedCrossRef 10. Hofreuter D, Odenbreit S, Haas R: Natural transformation competence in Helicobacter pylori is mediated by the basic components of a type IV Rabusertib concentration secretion system. Mol Microbiol 2001,41(2):379–391.PubMedCrossRef 11. Christie PJ, Atmakuri K, Krishnamoorthy V, Jakubowski S, Cascales E: Biogenesis, architecture, and function of bacterial type IV secretion systems. Annu Rev Microbiol 2005, 59:451–485.PubMedCrossRef 12. Christie PJ, Vogel JP: Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells. Trends Microbiol 2000,8(8):354–360.PubMedCrossRef 13. Hofreuter D, Odenbreit S, Henke G, Haas R: Natural competence for DNA transformation in Helicobacter pylori: identification and genetic characterization of the

comB locus. Mol Microbiol 1998,28(5):1027–1038.PubMedCrossRef 14. Lawley TD, Klimke WA, Gubbins MJ, Frost LS: F factor conjugation is a true type IV secretion system. FEMS Microbiol Lett 2003,224(1):1–15.PubMedCrossRef 15. Marra A, Blander SJ, Horwitz MA, Shuman HA: Identification of a Legionella pneumophila locus required for intracellular multiplication in human macrophages. Proc Natl Acad Sci USA 1992,89(20):9607–9611.PubMedCrossRef PIK3C2G 16. Zamboni DS, McGrath S, Rabinovitch M, Roy CR: Coxiella burnetii express type IV secretion Enzalutamide mw system proteins that function similarly to

components of the Legionella pneumophila Dot/Icm system. Mol Microbiol 2003,49(4):965–976.PubMedCrossRef 17. Juhas M, Crook DW, Dimopoulou ID, Lunter G, Harding RM, Ferguson DJ, Hood DW: Novel type IV secretion system involved in propagation of genomic islands. J Bacteriol 2007,189(3):761–771.PubMedCrossRef 18. Kurenbach B, Bohn C, Prabhu J, Abudukerim M, Szewzyk U, Grohmann E: Intergeneric transfer of the Enterococcus faecalis plasmid pIP501 to Escherichia coli and Streptomyces lividans and sequence analysis of its tra region. Plasmid 2003,50(1):86–93.PubMedCrossRef 19. Lipps G: Plasmids and viruses of the thermoacidophilic crenarchaeote Sulfolobus. Extremophiles 2006,10(1):17–28.PubMedCrossRef 20. Alvarez-Martinez CE, Christie PJ: Biological diversity of prokaryotic type IV secretion systems. Microbiol Mol Biol Rev 2009,73(4):775–808.PubMedCrossRef 21. Cascales E, Christie PJ: Definition of a bacterial type IV secretion pathway for a DNA substrate. Science 2004,304(5674):1170–1173.PubMedCrossRef 22. Segal G, Russo JJ, Shuman HA: Relationships between a new type IV secretion system and the icm/dot virulence system of Legionella pneumophila. Mol Microbiol 1999,34(4):799–809.PubMedCrossRef 23.

Am J Epidemiol 2008, 167:759–774.PubMedCrossRef 34. Adly L, Hill D, Sherman ME, Sturgeon

SR, Fears T, Mies C, Ziegler RG, Hoover RN, Schairer PLX4032 C: Serum concentrations of estrogens, sex hormone-binding globulin, and androgens and risk of breast cancer in postmenopausal women. Int J Cancer 2006, 119:2402–2407.PubMedCrossRef 35. Micheli A, Muti P, Secreto G, Krogh V, Meneghini E, Venturelli E, Sieri S, Pala V, Berrino F: Endogenous sex hormones and subsequent breast cancer in premenopausal women. Int J Cancer 2004, 112:312–318.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ AZD1390 nmr contributions JSL is responsible for editorial correspondence and has contributed to the conception and design of the study, the analysis and interpretation of data, the revision of the article as well as final approval of the version to be

submitted. YWJ and LHZ participated in the design of the study, performed the statistical analysis, searched and selected the trials, drafted and revised the article. TTY participated in the design of the study and helped to revise the article. ZZS conceived of the study, and participated in its design and coordination. ZMS conceived of the study, and participated in its design and coordination. All authors read and approved the final version of the manuscript.”
“Background A clinical report published in 1999, the RTOG (Radiation Therapy Oncology Group) 85-01 trial involving LXH254 nmr 134 patients with T1-3, N0-1 and M0 esophageal cancer, is of great interest in terms of clinical outcome because it demonstrated a 5-year survival rate of 26% [1]. This treatment consists of infusions of 5-fluorouracil (5-FU) and cisplatin (CDDP), and concurrent radiation, without next pre- or post-surgical resection. Simultaneously in Japan, a modified version

was proposed by Ohtsu and his co-workers for advanced metastatic esophageal cancer [2, 3]. Two independent clinical investigations have shown curative potential using this regimen for unresectable esophageal squamous cell carcinoma (ESCC) of T4 or M1a [2, 3]. A long-term evaluation of efficacy and toxicity with 139 patients revealed a complete response (CR) rate of 56%, along with a 5-year survival rate of 29% [4, 5]. Currently, definitive 5-FU/CDDP-based chemoradiotherapy is recognized as one of the most promising treatments for esophageal cancer [6]. A series of studies performed to find a marker predictive of clinical outcome after treatment with a definitive 5-FU/CDDP-based chemoradiotherapy found a genetic polymorphism, G-1154A, of vascular endothelial growth factor to be a predictor of severe acute leukopenia and cheilitis, and the plasma concentration of 5-FU to be predictive of clinical response [7–9]. Tumor necrosis factor (TNF)-α, a proinflammatory cytokine, plays a key role in the pathogenesis of inflammatory diseases.

Methods Chemicals and materials Pure (>98%) crystallized BSA from Fraction V was purchased from Sigma-Aldrich (St. Louis, MO, USA) and used without further purification. All other chemical reagents used in our experiment

were of analytical grade without further purification. All samples were prepared by Milli-Q super purified water with resistance >18 MΩ/cm (Millipore, Billerica, MA, USA). All solutions were filtered with 0.02-μm Anotop filter (Whatman, Maidstone, UK) before using. Nanopores were hydrated with the addition of degassed and filtered KCl electrolyte solution buffer. Electrolyte strength was typically 1 M/1 M KCl cis/trans in protein translocation studies. Nanopore fabrication The nanopore used in our study was fabricated in freestanding 100-nm-thick Selleck BAY 11-7082 silicon nitride membranes supported by a 300-μm-thick silicon wafer (Si 100) using focused ion beam (FIB) milling followed by feedback-controlled ion beam sculpting. The FEI Strata 201 (Hillsboro, OR, USA) was used with an acceleration voltage of 30 kV and ion current at 1 pA. A great variety of nanopore sizes were obtained in control of the ion dose and ion drilling time. The detailed process is referred to in previous studies [40]. The resulting pore was imaged by scanning electron microscopy (SEM). The pore diameter used in our experiment is about 60 nm, as shown in Figure 1b. Figure 1 Schematic illustrations of the microfluidic

setup and nanopore detection. (a) Schematic illustration of the microfluidic setup. A nanopore connects two compartments filled with an electrolyte solution (1 M/1 M KCl cis/trans), separated by a silicon nitride check details membrane. The application of an electric potential difference via two Ag/AgCl electrodes

generates an ionic current through the pore. (b) A SEM image of approximately Cepharanthine 60-nm nanopore fabricated by FIB, with a scale bar of 100 nm. (c) The schematic conformation of bovine serum albumin (BSA). Serum is a negatively charged globular protein with 583 residues and consists of three domains (I, II, III); the hydrodynamic diameter of the native state is about 10 nm learn more measured with dynamic light scattering at neutral condition. Experimental setup The schematic of the experimental setup is shown in Figure 1a. The nanopore-containing chip encapsulated with two PDMS films was immersed in ionic solutions, which was then divided into two isolated reservoirs; 1 M KCl salt solution was added into the two isolated reservoirs. Two Ag/AgCl electrodes were inserted into the reservoirs, respectively, and connected to a patch clamp amplifier (Axon Instruments, Axopatch 700B, Molecular Devices, Sunnyvale, CA, USA). The ionic current was filtered at 10 kHz and sampled using a 16-bit DAQ card (National Instruments, Austin, TX, USA) for a better signal-to-noise ratio, operated with homemade LabVIEW software. The whole fluidic device was put in a Faraday cage for shielding electromagnetic noise.

​chspr.​ubc.​ca/​cgi-bin/​pub University of Ottawa Evidence-based Practice Center (EPC), http://​www.​chalmersresearch​.​com/​old/​systematic_​reviews_​publications.​htm Australian Safety and Efficacy Register of New Interventional Procedures – Surgical (ASERNIP-S), http://​www.​surgeons.​org/​AM/​Template.​cfm?​Section=​Home&​Template=​/​Templates/​HomeRACS.​cfm

Department of Health and Ageing, Australian Government, http://​www.​health.​gov.​au/​internet/​main/​publishing.​nsf/​Content/​health-publicat.​htm Belgian Health Care Knowledge Centre, http://​www.​kce.​fgov.​be/​index_​en.​aspx?​SGREF=​5211 International Network of Agencies for Health Technology Assessment, http://​www.​inahta.​org/​ European network for Health Technology Assessment – EUnetHTA, http://​www.​eunethta.​net/​Public/​About_​EUnetHTA/​ buy Rapamycin Finnish Office for Health Technology Assessment (Finohta), Ulixertinib molecular weight National Research and Development Centre for Welfare and Health (STAKES), http://​finohta.​stakes.​fi/​EN/​index.​htm French National Authority for Health/Haute Autorité de santé (HAS), http://​www.​has-sante.​fr/​portail/​display.​jsp?​id=​c_​5443&​pcid=​c_​5443

German find more Institute of Medical Documentation and Information (DIMDI), Federal Ministry of Health, http://​www.​dimdi.​de/​dynamic/​en/​hta/​db/​index.​htm Health Service Executive (HSE)/Feidhmeannacht na Seirbhíse Sláinte, http://​www.​hse.​ie/​en/​Publications/​ Health Council of the Netherlands/De Gezondheidsraad, http://​www.​gezondheidsraad.​nl/​en Catalan Agency for Health Technology

Assessment and Research (CAHTA)/Agència d’Avaluació de Tecnologia i Recerca Mèdiques de Catalunya, http://​www.​gencat.​net Swedish Council on Technology Assessment in Health Care (SBU), http://​www.​sbu.​se/​en/​ Aggressive Research Intelligence Facility (ARIF), Department of Public Health and Epidemiology, Department of General Practice, and the Health Services Management Centre; University of Birmingham, http://​www.​arif.​bham.​ac.​uk Agency for Healthcare Research and Quality (AHRQ) (Technology Assessments), Anidulafungin (LY303366) http://​www.​ahrq.​gov/​clinic/​techix.​htm, http://​www.​ahrq.​gov/​clinic/​epcquick.​htm, http://​www.​ahrq.​gov/​clinic/​epc/​epcprogress.​htm Department of Veterans Affairs Research & Development, http://​www.​research.​va.​gov/​resources/​pubs/​default.​cfm, http://​www.​va.​gov/​vatap/​publications.​htm ECRI (Emergency Care Research Institute), http://​www.​ecri.​org/​ Institute for Clinical Systems Improvement (ICSI), http://​www.​icsi.​org University HealthSystem Consortium (UHC), http://​www.​uhc.​edu/​ Canadian Task Force on Preventive Health Care, http://​www.​ctfphc.​org/​list_​all_​topics.