After the change in substrate conditions it took the methano-archaeal community about 5-6 weeks to be affected but then changes occurred quickly. (C) 2014 Elsevier Ltd. All rights reserved.”
“Background. Standard

treatment of patients with T4b squamous cell head and neck cancer (T4b-SCHNC) is concomitant chemo-radiotherapy (CT-RT). Recent Phase III trials with Taxane containing induction chemotherapy (IC) suggest that IC could also play a role in this setting. selleck compound The value of resecting the residual mass after IC and before RT is not yet clear in this context. Methods. We present the results of a retrospective analysis. Results. Between 1984 and 2001, 113 patients (patients) with T4b-SCHNC were treated at our institution with IC. Four patients dead during IC and 57 patients achieved a complete or a 90% partial response at primary and proceeded to definitive RT (or concomitant CT/RT). Surgical resection was reconsidered after IC and before RT in the other 52 patients. Surgery was performed in 13 of them: in 7 patients

resection was R1, all of them had loco-regional Nutlin 3 progression (2 also developed systemic metastases) and median OS after surgery was 21 months, with no patient alive at 48 months. In the other 6 patients a R0 resection was performed: 3 of these patients had loco-regional relapses (1 also developed systemic metastases) and the other 3 patients remain alive and disease free 56, 62 and 72 months after surgery. Considering the 52 patients that achieved less than a 90% partial response at primary with IC, overall survival

was equivalent when no Resection or an R1 resection was performed after IC (5 year OS 8 vs. 0%, lrk, p=0.74), but a statistically significant improvement in OS was observed when an R0 resection was obtained (5 years OS 50%, lrk, p=0.02). Conclusions: R0 resections after IC and before RT could indicate an improvement in OS in patients with T4b-SCHNC that obtain less than a 90% PR at primary after IC. We consider that this approach deserves further research in prospective clinical trials.”
“Recently, attention has been drawn toward the occurrence of pharmaceuticals in the environment. Milciclib chemical structure In recent years, many reports have been made on the occurrence of the large, differentiated group of pharmaceuticals in wastewater (PW), surface water, ground water, and in soil. The pharmaceutical sector is currently expanding in Tunisia, with more than 34 industries. The aim of this work was to evaluate the ability of Pseudomonas putida mt-2 to treat PW. P. putida was very efficient in reducing chemical oxygen demand (COD), total dissolved solids (TDS), and turbidity of solution (85.5, 89.1, and 81.5%, respectively). Genotoxicity of effluent, before and after biodegradation, was evaluated in vivo in mouse bone marrow by assessing the percentage of cells bearing different chromosome aberrations. Results indicated that PW showed a significant ability to induce DNA damage.

56, 95% Cl 1.06-2.29 comparing highest with lowest quartile of film alcohol exposure) and binge drinking KU-57788 ic50 (1.59, 95% Cl 1.10-2.30) were attenuated by adjustment for gender, social class, family background (parental structure, parental care and parental control), attitudes to risk-taking and rule-breaking, and qualifications (OR heavy drinking 1.42, 95% Cl 0.95-2.13 and binge drinking 1.49, 95% Cl 1.01-2.19), and further so when adjusting for

friends’ drinking status (when the odds ratios were no longer significant). A similar pattern was seen for ever use of cannabis and ‘hard’ drugs (unadjusted OR 1.80, 95% Cl 1.24-2.62 and 1.57, 95% Cl 0.91-2.69 respectively, ‘fully’ adjusted OR 1.41 (0.90-2.22 and 1.28 (0.662.47) respectively).\n\nConclusions: Despite some limitations, which are discussed, these cross-sectional results add to a body of work which suggests that it is important to design good longitudinal studies which can determine whether exposure to images of potentially health-damaging behaviours lead to uptake of these behaviours during adolescence and early adulthood, and to examine factors that might mediate this relationship.”
“BACKGROUND AND OBJECTIVE: To present the clinical outcomes of the Neusidl Corneal Inserter (NCI) (Fischer Surgical, Imperial, MO), a new donor inserter for Descemet’s stripping automated endothelial keratoplasty (DSAEK).\n\nPATIENTS AND METHODS: Six eyes of 6 Japanese

patients (mean age = 74.0 years) with endothelial dysfunction were enrolled in this prospective, non-comparative study. All patients had a small MEK inhibitor cornea of 9.0 mm or less in diameter. A donor was inserted into the eye using NCI. Intraoperative and postoperative click here complications, postoperative donor endothelial cell densities (ECD), and best-corrected visual acuity (BCVA) were evaluated.\n\nRESULTS:

Donor loading onto NCI was successful in all cases. No intraoperative or postoperative complications were noted. All cases reached more than 20/63 BCVA within 12 months. Mean ECD was 2,441 cells/mm(2) (mean loss = 22.1%) at 6 months and 2,159 cells/mm(2) (mean loss = 31.0%) at 12 months.\n\nCONCLUSION: Graft insertion with NCI is safe in DSAEK with low endothelial cell loss. [Ophthalmic Surg Lasers Imaging 2012;43:311-318.]“
“Aim The aim of this study is to look at the weak points of tension-free vaginal mesh (TVM) operation for pelvic organ prolapse by reviewing recurrent cases. Methods Five hundred and twenty-six transobturator TVM operations were performed at the University of Occupational and Environmental Health hospital from August 2006 to December 2011. Thirty-seven patients with pelvic organ prolapse quantification (POP-Q) stage II or higher after their initial operations were diagnosed as recurrent and were enrolled in the present study. The patients’ characteristics, procedures of the initial and second operations, and the recurrence rates in the pelvic organs were retrospectively reviewed.

The fact that YbdT is a peroxidase could explain why

biosurfactant production is rarely observed in anaerobically grown Bacillus species. Manipulation of LCFA specificity of YbdT could provide a new route to produce biosurfactants with activities tailored to specific functions.”
“When English-speaking people listen to the Deutsch “high-low” word illusion, they report hearing English words. Whether Chinese-speaking people report Chinese words when listening to the illusion, or whether any reported words might be correlated with personality traits as previous investigations have demonstrated for listening to music in other cultures, is open to question. The present study aimed to address this.\n\nA total of 308 right-handed,

healthy volunteers (177 women and 131 men) were given the illusion test and asked to answer the Zuckerman-Kuhlman learn more personality questionnaire (ZKPQ). Their depressive tendency was measured by the Plutchik-van Praag depression inventory (PVP).\n\nThere was no gender effect regarding either the PVP SRT1720 price score or the number of reported Chinese words from the illusion. Women scored higher on ZKPQ neuroticism-anxiety than men. The number of meaningful Chinese words reported was correlated with the ZKPQ impulsive sensation-seeking, aggression-hostility, and activity scores. Some words reported by participants who scored higher on these three traits were related in meaning to those scales.\n\nOur preliminary results suggest that when Chinese-speaking people listen to the Deutsch “high-low” word illusion, they might use personality-related, specific cognitive schemata.”
“Little is known about the effect of MICA antibodies (Abs) on cardiac allograft function and survival. Pretransplant and posttransplant serum from 491 and 196 adult cardiac allograft recipients, respectively, has been investigated for MICA Abs, donor specificity

and the effect of MICA Abs on graft survival, acute rejection episodes (AR) and cardiac allograft vasculopathy (CAV). Patients with HLA Abs (11.6%) were excluded from the analysis. A total of 11.8% of patients had MICA Abs, without HLA Abs, before their transplant. Actuarial graft survival demonstrated slightly better survival of patients with donor-specific Selleck LCL161 MICA Abs at 1 and 5 years (88.9% and 83.3%) than patients negative for MICA Abs (72% and 63.7%, p = 0.051). After transplantation, 15.8% of patients produced MICA Abs, and in 17 patients these were produced de novo. There was no effect of pretransplant or posttransplant production of MICA Abs on numbers of AR episodes in year 1, or CAV assessed at years 3 and 5. Immunocytochemistry of cardiac biopsies from 11 patients did not demonstrate a presence of MICA. Sera from only 4/69 patients with MICA Abs fixed complement prior to transplantation and from 7/38 patients following transplantation.

\n\nResults.

In the pigs with AIA, plain histologic analysis revealed severe arthritic changes in the synovium. Safranin O and CII staining showed decreased proteoglycan and CII content in cartilage. Immunohistochemistry analysis revealed increased levels of IL-6 and VEGF in synovium and cartilage, and protein concentrations of IL-6, VEGF, IL-1 beta, and IGF-1 in synovium and cartilage were elevated as well; in addition, TNF alpha protein was increased in cartilage. Treatment with PRP led to attenuation of these arthritic changes in the synovium and cartilage.\n\nConclusion. We have described a porcine model of AIA. Experiments using this model demonstrated that PRP can attenuate arthritic changes as assessed histologically and based on protein synthesis of typical inflammatory mediators in the synovial https://www.selleckchem.com/products/epz-5676.html membrane and cartilage.”
“The quest to decipher protein

alterations in cancer has spanned well over half a century. the vast dynamic range of protein abundance coupled with a plethora of isoforms and disease heterogeneity have been formidable challenges. Progress in cancer proteomics has substantially paralleled technological developments. Advances in analytical techniques and the implementation of strategies to de-complex the proteome into manageable components have allowed proteins across a wide dynamic range to be explored. the massive amounts of data that can currently be collected through

proteomics allow the near-complete definition of cancer subproteomes, which reveals the alterations in signalling and developmental pathways. this allows the discovery of predictive C59 biomarkers and the annotation of the cancer genome based on proteomic findings. there remains a considerable need for infrastructure development and the organized collaborative efforts to efficiently mine the cancer proteome.”
“Sheep-associated malignant catarrhal fever (SA-MCF) caused by ovine herpesvirus-2 (OvHV-2), a gamma-herpesvirus in the Macavirus genus, is a fatal disease associated with lymphoproliferation, lymphocytic vasculitis, and PRT062607 research buy mucosal ulceration in clinically susceptible species. SA-MCF is an important threat to American bison (Bison bison) due to their high susceptibility to this disease. Currently, the pathogenesis of disease in SA-MCF is poorly understood, and the immunophenotype of lymphocytes that infiltrate the vascular lesions of bison and cattle with SA-MCF has been only partially defined. Previous single-color immunohistochemistry studies have demonstrated that CD8(+) cells and CD4(+) cells predominate within vascular infiltrates in cattle and bison. The CD8(+) cells detected in the vascular lesions of cattle and bison were assumed to be cytotoxic alpha beta T lymphocytes. However, polychromatic immunophenotyping analyses in this study showed that CD8(+)/perforin.

These 3 variables are combined in a model to explain over 50% of the variance of individual BVOC emission fluxes measured. The modeled results of litter emissions were compared with above-canopy fluxes. Litter emissions constituted less than 1% of above-canopy emissions for all BVOCs measured. A comparison of terpene oil pools in litter and live needles with above-canopy fluxes suggests that there may be another canopy terpene source in addition to needle storage or that some terpene emissions may be light-dependent.\n\nGround NVP-BSK805 inhibitor enclosure measurements indicated

that compensation point concentrations of BVOCs (equilibrium between BVOC emission and deposition) were usually higher than ambient air concentrations at the temperature of the measurements. (C) 2012 Elsevier Ltd. All rights reserved.”
“This study aimed to investigate the feasibility of nanostructured 3D poly(lactide-co-glycolide) (PLGA) constructs, which are loaded with dexamethasone (DEX) and growth factor embedded heparin/poly(L-lysine) nanoparticles by a layer-by-layer system, to serve as an effective scaffold for nucleus pulposus (NP) tissue engineering. Our results demonstrated that the microsphere constructs were

capable of simultaneously releasing basic fibroblast growth factor and DEX with approximately zero-order kinetics. The dual bead microspheres showed no cytotoxicity, and promoted the proliferation GSI-IX purchase of the rat mesenchymal stem cells (rMSCs) by lactate dehydrogenase assay and CCK-8 assay. After 4 weeks of culture in vitro, the rMSCs-scaffold hybrids contained significantly higher levels of sulfated GAG/DNA and type-II collagen than the control samples. Moreover, quantity real-time PCR analysis revealed that the expression of disc-matrix proteins, including type-II collagen, aggrecan and versican, in the rMSCs-scaffold hybrids was significantly higher than the

control group, whereas the expression of osteogenic differentiation marker type-I collagen was decreased. Taken together, these data indicate that the heparin bound bFGF-coated and DEX-loaded PLGA microsphere constructs is an effective bioactive scaffold for the regeneration of NP tissue. (C) Koninklijke Brill NV, Leiden, 2012″
“Background: Recent studies have shown that mammalian milk represents a continuous supply of commensal VX-661 bacteria, including enterococci. The objectives of this study were to evaluate the presence of enterococci in milk of different species and to screen them for several genetic and phenotypic traits of clinical significance among enterococci. Results: Samples were obtained from, at least, nine porcine, canine, ovine, feline and human healthy hosts. Enterococci could be isolated, at a concentration of 1.00 x 10(2) -1.16 x 10(3) CFU/ml, from all the porcine samples and, also from 85, 50, 25 and 25% of the human, canine, feline and ovine ones, respectively.

\n\nResults: Six trials involving 1476 patients with previously untreated E-SCLC were ultimately

analyzed. The intention-totreatment analysis indicated that IP regimens could acquire more overall response than EP regimens (relative risk = 1.10, 95% confidence interval [CI] : 1.00-1.21, p = 0.043). The pooled HR showed that IP could prolong OS (HR = 0.81, 95% CI: 0.66-0.99, p = 0.044). Nevertheless, the pooled HR failed to show a favorable PFS in IP regimens (HR = 0.82, 95% CI: 0.64-1.06, p = 0.139). IP regimens led to less grade 3 to 4 anemia, neutropenia, and thrombocytopenia but more grade 3 to 4 vomiting and diarrhea than EP regimens. Treatment-related deaths were comparable between the two groups.\n\nConclusion: Although the PFS was similar from this meta-analysis, our results Crenolanib suggest that IP might have an advantage in overall response and OS compared with EP with less hematological toxicities. The IP regimens may be an alternative of EP regimens YH25448 supplier in the first-line treatment of E-SCLC.”
“Stereology is a set of mathematical and statistical tools to estimate three-dimensional (3-D) characteristics of objects from regular two-dimensional (2-D) sections. In medicine and biology, it can be used to estimate features such as cell volume, cell membrane surface area, total length of blood vessels per volume tissue

and total number of cells. The unbiased quantification of these 3-D features allows for a better understanding of morphology in vivo compared with 2-D methods. This review provides an introduction to the field of stereology with specific emphasis on the application of stereology to dermatological research by supplying a short insight into the theoretical basis behind the technique and selleck chemicals llc presenting previous dermatological studies in which stereology was an integral part. Both the theory

supporting stereology and a practical approach in a dermatological setting are reviewed with the aim to provide the reader with the capability to better assess papers employing stereological estimators and to design stereological studies independently.”
“Tomato (Lycopersicon esculentum) is important widely grown vegetable in India and its productivity is affected by bacterial wilt disease infection caused by Ralstonia solanacearum. To prevent this disease infection a study was conducted to isolate and screen effective plant growth promoting rhizobacteria (PGPR) antagonistic to R. solanacearum. A total 297 antagonistic bacteria were isolated through dual culture inoculation technique, out of which forty-two antagonistic bacteria were found positive for phlD gene by PCR amplification using two primer sets Phl2a:Phl2b and B2BF:BPR4. The genetic diversity of phlD (+) bacteria was studied by amplified 16S rDNA restriction analysis and demonstrated eleven groups at 65% similarity level.

(c) 2008 Elsevier Inc. All rights reserved.”
“Background-The availability of more sensitive biomarkers of myonecrosis and a new classification system from the universal definition of myocardial infarction (MI) have led to evolution of the classification of CYT387 ic50 MI. The prognostic implications of MI defined in the current era have not been well described.\n\nMethods and Results-We

investigated the association between new or recurrent MI by subtype according to the European Society of Cardiology/American College of Cardiology/American Heart Association/World Health Federation Task Force for the Redefinition of MI Classification System and the risk of cardiovascular death among 13 608 patients with acute coronary syndrome in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel-Thrombolysis in Myocardial Infarction 38 (TRITON-TIMI 38). The adjusted risk of cardiovascular death TH-302 price was evaluated by landmark analysis starting at the time of the MI through 180 days after the event. Patients who experienced an MI during follow-up had a higher risk of cardiovascular death at 6 months

than patients without an MI (6.5% versus 1.3%, P<0.001). This higher risk was present across all subtypes of MI, including type 4a (peri-percutaneous coronary intervention, 3.2%; P<0.001) and type 4b (stent thrombosis, 15.4%; P<0.001). After adjustment for important clinical covariates, the occurrence of any MI was

associated with a 5-fold higher risk of death at 6 months (95% confidence interval 3.8-7.1), with similarly increased risk across subtypes.\n\nConclusions-MI is associated with a significantly increased risk of cardiovascular death, with a consistent relationship across all types as defined by the universal classification system. These findings underscore the clinical relevance of these events and the importance of therapies aimed at preventing MI.”
“Mutations in or ablation of the gene encoding caveolin-3, Selleck CP 868596 a protein of muscle cell caveolae, result in forms of muscular dystrophy and cardiomyopathy. Another member of the caveolin gene family, caveolin-1, is widely considered not to be expressed in myocytes, yet ablation of the gene encoding this protein in mice also results in cardiomyopathy. By applying the high-resolution electron-microscopical imaging technique of freeze-fracture replica immunolabelling, we report here evidence that caveolin-1 is expressed in human cardiac myocytes, localized to both caveolae and non-caveolar domains in the plasma membrane. Disorders of the myocyte resulting from defects in caveolin-1 may thus arise directly, at the level of the myocyte, rather than via other cell types as previously proposed.

02 smaller than = Ds smaller than = 0.09) indicate minimal population differentiation within Ecuadorian capuli. However, Bayesian population structure analysis suggests a subtle genetic contrast between germplasm from the Northern and Southern highlands. Certainly, it is of interest to analyze whether this underlying genetic differentiation between the Northern- and Southern-Highland groups is also manifested in morphological, agronomic or other phenotypic characters that could indicate adaptive differences to divergent agro-ecosystems. (C) YM155 inhibitor 2015 Elsevier Ltd. All rights reserved.”
“Cutaneous

leishmaniasis in Ethiopia is caused mainly by Leishmania aethiopica. In this study, the response of L aethiopica to sodium stibogluconate (SSG) and liquid nitrogen in Silti has been investigated. Patients were divided into two groups by the treating physician and were treated with either liquid

beta-catenin inhibitor nitrogen or SSG. Punch biopsy samples were collected from 54 patients with mean age of 20.61 (+/- 9.87 SD) years for histological characterization. The histological spectrum found to be type-1, type-2, type-3 and type-4 were 37.0%, 3.7%, 37.0% and 22.2% respectively. One hundred and three patients with a mean age of 18.4 (+/- 11.7 SD) years were treated with liquid nitrogen. The mean duration of the lesions before the onset of treatment was 8.5 months (+/- 6.7 SD). Of the 103 patients 80.6% (83/103) were cured, 13.6% (14/103) were dropouts and 5.8% (6/103) did not respond. Twenty patients with a mean age of 19.55 (+1.64 SD) years A-1155463 mouse were treated with Pentostam on conventional dose. Of the 20 patients 85.0% (17/20) were cured, 10.0% (2/20) were unresponsive and 5.0% (1/20) were dropouts. The per protocol cure rate for cryotherapy and Pentostam was 93.3% and 89.5% respectively. Hence, liquid nitrogen can be used as one of the treatment options especially in resource poor settings. (C) 2012 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.”
“Myeloid differentiation factor 88 (MyD88) is a key adaptor of Toll-like receptor signaling, which

plays a critical role in dendritic cell (DC) function. However, its role in the induction of transplant tolerance by immature DCs is unknown. In this study, we silenced MyD88 expression of bone marrow-derived immature DCs with small interference RNA demonstrating that this maneuver significantly prolonged the survival of intestinal allografts. This study provided evidence that the absence of MyD88 enhances the tolerogenicity of DCs and suggested that inhibiting innate immunity may be a potential strategy to facilitate induction of transplant tolerance by DCs.”
“The plant Withania somnifera (WS), also known as Ashwagandha, has been used widely in traditional medicine systems in India and Nepal (Ayurveda), and has been accepted to cure various ailments.

01). A significantly decreased breast cancer risk was observed in clerks (OR=0.59, 95% CI=0.37-0.96). In conclusion, this study revealed that women who have lifetime occupation in an industrial setting may have higher risk to develop OSI-744 datasheet breast cancer. Further studies are needed to assess occupational exposure in specific occupations.”
“Introduction: There is no available information about the effects of remifentanil labor analgesia on newborns’

vital signs in the first hours after delivery. The aim of the study was to assess changes in the heart rate, blood pressure and oxygen saturation during the first 24 h of neonatal life after using remifentanil patient-controlled analgesia (PCA) for labor analgesia.\n\nMaterial and methods: Forty-four full-term neonates, 23 from intravenous PCA remifentanil labor anesthesia GDC-0068 cell line 0.2 mu g/kg, repeated not more frequently than every 2 min, and 21 born to mothers without any pharmacological forms of analgesia, were studied. Heart rate, oxygen saturation, and systolic (SBP) and diastolic blood pressure (DBP) were monitored using a Nellcor Oxi Max monitor N5500 (Tyco Healthcare), and recorded at 1 h, 6 h, 12 h and 24 h.\n\nResults: No significant differences in heart rate (p = 0.54; p = 0.26; p = 0.60; p = 0.83), oxygen

saturation (p = 0.21; p = 0.27; p = 0.61; p = 0.9) and DBP (p = 0.98; p = 0.31; p = 0.83; p = 0.58) between the groups at 1 h, 6 h, 12 h and 24 h. Newborns from the remifentanil group had lower SBP at 1 h of life (59 mm Hg vs. 68.5 mm Hg) but the difference was just on the borderline of statistical significance (p > 0,06). There were no significant differences in SBP between the groups at 6 h (p = 0.65), 12 h (p = 0.11), and 24 h (p = 0.89) of life.\n\nConclusions: Remifentanil PCA analgesia during labor does not significantly find more modify the oxygen saturation,

heart rate and blood pressure in infants during the first day of their life. Therefore, further studies are needed to explain the observed trend for arterial hypotension in the first hour of life in infants born to mothers treated with remifentanil.”
“A test-system based on enzyme-linked immunosorbent assay (ELISA) for the quantitative detection of chloramphenicol (CAP) in foodstuff has been developed. The detection limit of the method was 0.05 mu g/l. The procedures for milk samples preparation of various fat content and chicken muscles were optimized. Before the analysis milk was diluted 5-fold with a buffer. The detection limit for milk was 0.3 mu g/l; recoveries varied from 74 to 118%. Two protocols for chicken muscles preparation were elaborated; extraction with buffer (the express method) and extraction with acetonitrile. The detection limits of CAP in chicken muscles were 0.5 and 0.3 mu g/kg, respectively; recovery values were 71-107% and 95-115%, respectively.

We examined the diagnostic and prognostic significance of ECG changes during

vasodilator single photon emission computerized tomography (SPECT) MPI.\n\nWe studied consecutive patients who underwent vasodilator SPECT MPI from 1995 to 2009. Patients with baseline ECG abnormalities, PF-04929113 cell line previous history of coronary artery bypass graft surgery or myocardial infarction (MI) were excluded. Significant coronary artery disease (CAD) was defined as > 70% stenosis of any vessel or a parts per thousand yen50% stenosis of left main. Mean follow-up was 2.4 +/- A 1.5 years for cardiac events (cardiac death and non-fatal MI).\n\nOf patients in the diagnostic cohort, ST depression was associated with increased incidence of CAD with abnormal (P = .020 and P <.001) but not in those with normal perfusion (P = .342). Of 3,566 patients with follow-up in the prognostic cohort, including 130 (5.0%) with ST depression and normal perfusion, the presence of ST depression a parts per thousand yen1 mm did not affect the outcomes in any summed stress score category.\n\nST depression a parts per thousand yen1 mm during vasodilator Elafibranor inhibitor SPECT MPI is associated with CAD in patients with abnormal perfusion, but provides no additional risk stratification beyond concomitant

perfusion imaging, including those with normal studies.”
“We report a rare and severe nasal presentation of antiphospholipid syndrome in a 41-year-old man with systemic lupus erythematosus and end-stage renal disease. His nasal signs included total Rigosertib cell line septal necrosis, along with external nasal swelling and erythema. Prior to the correct diagnosis, multiple medical and surgical treatments were attempted without success. After

initiation of intravenous immunoglobulin and anticoagulation therapy, his nasal symptoms promptly resolved. The nasal complication of antiphospholipid syndrome is a relatively unknown and rare finding with limited discussion in the otolaryngology literature.”
“PURPOSE\n\nWe aimed to determine the prevalence of enlarged lymph nodes (LNs) in chest computed tomography (CT) scans of patients with a history of sternotomy.\n\nMATERIALS AND METHODS\n\nThe chest CT scans of 271 patients with a history of sternotomy (mean age, 68.3 +/- 14.4 years; range, 15-93 years; 178 males) were retrospectively scored in a blind and random manner for the presence, size, and location of enlarged LNs. Scans with known etiologies for enlarged LNs were excluded. Serial scans were available for 15 patients with enlarged LNs. Twenty patients (mean age, 61.2 +/- 7.0 years; range, 54-64 years; 15 males) that had cardiac CT data with no cardiac surgery were included as controls.\n\nRESULTS\n\nOf the 271 patients, 189 had other identifiable etiologies for enlarged LNs. Of the remaining 82 patients, 36 (44%) demonstrated enlarged LNs. None of the control patients presented with enlarged LNs (n=20). The mean size of the enlarged nodes was 13.0 +/- 2.0 mm.